About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcl11em1Groj
endonuclease-mediated mutation 1, Joanna R Groom
MGI:7618973
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cxcl11em1Groj/Cxcl11em1Groj C57BL/6J-Cxcl11em1Groj MGI:7618975


Genotype
MGI:7618975
hm1
Allelic
Composition		 Cxcl11em1Groj/Cxcl11em1Groj
Genetic
Background		 C57BL/6J-Cxcl11em1Groj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl11em1Groj mutation (0 available); any Cxcl11 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:345391 )
N
• no significant differences are found in adaptive immune responses to LCMV or influenza infection
increased CD8-positive, alpha-beta T cell number ( J:345391 )
• small but consistent increase in the frequency of CD8+ T cells in the spleen resulting in a minor increase in numbers compared to C57BL/6J controls
abnormal B cell morphology ( J:345391 )
• small but consistent decrease in the frequency of B220+ cells compared to C57BL/6J controls

hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:345391 )
• small but consistent increase in the frequency of CD8+ T cells in the spleen resulting in a minor increase in numbers compared to C57BL/6J controls
abnormal B cell morphology ( J:345391 )
• small but consistent decrease in the frequency of B220+ cells compared to C57BL/6J controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory