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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcl11em1Groj
endonuclease-mediated mutation 1, Joanna R Groom
MGI:7618973
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cxcl11em1Groj/Cxcl11em1Groj C57BL/6J-Cxcl11em1Groj MGI:7618975


Genotype
MGI:7618975
hm1
Allelic
Composition		 Cxcl11em1Groj/Cxcl11em1Groj
Genetic
Background		 C57BL/6J-Cxcl11em1Groj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl11em1Groj mutation (0 available); any Cxcl11 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:345391 )
N
• no significant differences are found in adaptive immune responses to LCMV or influenza infection
increased CD8-positive, alpha-beta T cell number ( J:345391 )
• small but consistent increase in the frequency of CD8+ T cells in the spleen resulting in a minor increase in numbers compared to C57BL/6J controls
abnormal B cell morphology ( J:345391 )
• small but consistent decrease in the frequency of B220+ cells compared to C57BL/6J controls

hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:345391 )
• small but consistent increase in the frequency of CD8+ T cells in the spleen resulting in a minor increase in numbers compared to C57BL/6J controls
abnormal B cell morphology ( J:345391 )
• small but consistent decrease in the frequency of B220+ cells compared to C57BL/6J controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory