Analysis Tools
adipose tissue
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• mice fed a high fat diet exhibit reduced fat mass compared to controls
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• mice fed a high fat diet exhibit enhanced expression of thermogenic genes in the brown adipose tissue
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• adipocytes of mice fed a high fat diet exhibit shrunk lipid droplets
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• mice fed a high fat diet exhibit reduced hypertrophy of the white adipose tissue
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growth/size/body
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• mice fed a high fat diet exhibit reduced fat mass compared to controls
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• mice fed a high fat diet are protected against diet-induced obesity, showing reduced body weight, fat mass, and hypertrophy of the white adipose tissue, shrunk lipid droplets, enhanced expression of thermogenic genes in the brown adipose tissue, and higher whole-body energy expenditure as shown by increased heat production, CO2 generation, and O2 consumption
• however, no change in body composition is seen in mice fed a standard chow diet
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liver/biliary system
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• mice fed a high-fat diet show decreased hepatic triglyceride levels compared to controls
• however, hepatic triglyceride levels are unchanged in mice fed a chow diet
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• mice fed a chow diet show a slight reduction in the ratio of liver weight relative to body weight
• mice fed a high fat diet exhibit decreased liver weight/body weight ratio
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• mice show alleviation of high fat diet-induced hepatic steatosis, indicated by decreased liver weight/body weight ratio value, heaptocytes lipid droplets size, and ballooning degree ratio
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homeostasis/metabolism
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• mice fed a chow diet show improved pyruvate tolerance
• however, pyruvate tolerance are not affected in mice fed a high fat diet
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• mice fed a chow diet show a slight decrease in fasting blood glucose compared to controls
• mice fed a high fat diet exhibit decreased fasting blood glucose levels compared to controls
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• mice fed a high-fat diet show decreased serum triglyceride levels compared to controls
• however, serum triglyceride levels are unchanged in mice fed a chow diet
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• mice fed a high fat diet exhibit higher whole-body energy expenditure as shown by increased heat production, CO2 generation, and O2 consumption
• however, no difference in basal metabolism is seen when mice are fed a standard chow diet
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• mice fed a high fat diet are protected against diet-induced obesity, showing reduced body weight, fat mass, and hypertrophy of the white adipose tissue, shrunk lipid droplets, enhanced expression of thermogenic genes in the brown adipose tissue, and higher whole-body energy expenditure as shown by increased heat production, CO2 generation, and O2 consumption
• however, no change in body composition is seen in mice fed a standard chow diet
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• mice fed a chow diet show improved glucose tolerance
• mice fed a high fat diet exhibit improved glucose tolerance
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• mice fed a chow diet show improved insulin sensitivity compared to wild-type controls
• however, insulin sensitivity is not affected in mice fed a high fat diet
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• mice fed a high-fat diet show decreased hepatic triglyceride levels compared to controls
• however, hepatic triglyceride levels are unchanged in mice fed a chow diet
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