Phenotypes associated with this allele

• Allele Symbol: Rnf123^em2Nmea
• Allele Name: endonuclease-mediated mutation 2, Division of Experimental Animals Nagoya University
• Allele ID: MGI:7619961
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf123^em2Nmea/Rnf123^em2Nmea	NC/Jic-Rnf123^em2Nmea	MGI:7619980

Genotype
MGI:7619980

hm1

• Allelic Composition: Rnf123^em2Nmea/Rnf123^em2Nmea
• Genetic Background: NC/Jic-Rnf123^em2Nmea

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to parasitic infection ( J:327312 )

• mice exhibit decreased susceptibility to lethal type of rodent malaria, Plasmodium yoelii 17XL, showing lower parasitemia 5 days post-infection compared to wild-type mice and increased survival rates, with about 40% surviving to 8 days post-infection, when all wild-type mice die, and about 5% surviving up to 21 days post-infection

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:327312 )

• mice exhibit increased survival rates when infected with a lethal type of rodent malaria, Plasmodium yoelii 17XL, with about 40% surviving to 8 days post-infection, when all wild-type mice die, and about 5% surviving up to 21 days post-infection

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:327312 )

• mice exhibit increased survival rates when infected with a lethal type of rodent malaria, Plasmodium yoelii 17XL, with about 40% surviving to 8 days post-infection, when all wild-type mice die, and about 5% surviving up to 21 days post-infection

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:327312 )

• mean corpuscular hemoglobin concentration (MCHC) is increased

• however, mice do not show pathological abnormalities in red blood cells

decreased mean corpuscular volume ( J:327312 )