Phenotypes associated with this allele

• Allele Symbol: Hsd3b6^tm1.2Hokh
• Allele Name: targeted mutation 1.2, Hitoshi Okamura
• Allele ID: MGI:7621194
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsd3b6^tm1.2Hokh/Hsd3b6^tm1.2Hokh	involves: C57BL/6 * C57BL/6JJcl * DBA	MGI:7621267

Genotype
MGI:7621267

hm1

• Allelic Composition: Hsd3b6^tm1.2Hokh/Hsd3b6^tm1.2Hokh
• Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

Meibomian gland atrophy ( J:347048 )

• severe atrophy of the meibomian gland by 2 months of age and by 6 months of age, atrophy is exacerbated and gland dropout is seen

• however, no difference in the number of meibomian ducts is seen

increased tear production ( J:347048 )

• mice exhibit increased tear volume when eyes are exposed to air for 1 hour, indicating a compensatory tear production to alleviate the dry eye phenotype

dry eyes ( J:347048 )

• mice exposed to imposed desiccation by exposing eyes to air for 1 hour exhibit the evaporative dry eye phenotype based on increased fluorescein staining

• surgical removal of the lacrimal gland leads to a more obvious evaporative dry eye phenotype than in wild-type mice

homeostasis/metabolism

abnormal testosterone level ( J:347048 )

• testosterone levels in the meibomian gland are decreased to about 50%

• testosterone levels in the meibomian gland are decreased to about 10% post-castration

endocrine/exocrine glands

Meibomian gland atrophy ( J:347048 )

• severe atrophy of the meibomian gland by 2 months of age and by 6 months of age, atrophy is exacerbated and gland dropout is seen

• however, no difference in the number of meibomian ducts is seen

abnormal Meibomian gland physiology ( J:347048 )

• meibomian glands exhibit reduced cell proliferation

• testosterone levels in the meibomian gland are decreased to about 50%

• testosterone levels in the meibomian gland are decreased to about 10% post-castration

integument

Meibomian gland atrophy ( J:347048 )

• severe atrophy of the meibomian gland by 2 months of age and by 6 months of age, atrophy is exacerbated and gland dropout is seen

• however, no difference in the number of meibomian ducts is seen

abnormal Meibomian gland physiology ( J:347048 )

• meibomian glands exhibit reduced cell proliferation

• testosterone levels in the meibomian gland are decreased to about 50%

• testosterone levels in the meibomian gland are decreased to about 10% post-castration