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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cpsf6em1Bcgen
endonuclease-mediated mutation 1, Biocytogen LLC
MGI:7621294
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cpsf6em1Bcgen/Cpsf6+ Not Specified MGI:7621295


Genotype
MGI:7621295
ht1
Allelic
Composition		 Cpsf6em1Bcgen/Cpsf6+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpsf6em1Bcgen mutation (0 available); any Cpsf6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:346988 )
• males have clear epididymides without sperm

immune system
increased interferon-beta secretion ( J:346988 )
• BMDMs infected with VSV-eGFP show greater IFN-beta production
decreased susceptibility to Riboviria infection ( J:346988 )
• bone marrow-derived macrophages (BMDMs) infected with vesicular stomatitis virus (VSV-eGFP) show lower viral load

cellular
azoospermia ( J:346988 )
• males have clear epididymides without sperm




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory