Analysis Tools
homeostasis/metabolism
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• mice injected with tamoxifen and fed the CDE-diet show reduced serum levels of alanine transaminase, indicating reduced liver injury compared to controls
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• mice injected with tamoxifen and fed the CDE-diet show reduced serum levels of aspartate aminotransferase, indicating reduced liver injury compared to controls
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• mice injected with tamoxifen at 8 weeks of age, followed by a 2 weeks of tamoxifen washout, and then fed a choline-deficient diet supplemented with ethionine (CDE) to induce liver injury (activates liver progenitor cells by transiently inhibiting hepatocyte proliferation) exhibit attenuated ductular reaction, liver inflammation, and liver fibrosis
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immune system
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• mice injected with tamoxifen and fed the CDE-diet show a reduction in the proportion of liver-infiltrating CD8+ T lymphocytes and glucocorticoid-induced tumor necrosis factor receptor (GITR)-positive CD8+ T lymphocytes
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• mice injected with tamoxifen and fed the CDE-diet show no increase in GITR+ proportion of CD45+CD3+ T lymphocytes after a 9 week CDE diet, indicating lowered numbers of activated CD45+CD3+ T lymphocytes
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• mice injected with tamoxifen and fed the CDE-diet show attenuated liver inflammation, with reduced liver-infiltrating CD8+ T lymphocytes, no increase in the proportion of activated CD45+CD83+ T lymphocytes, no reduction in the proportion of CD4+ T lymphocytes, and reduced immune cells around the portal area at 9 weeks after CDE injury
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liver/biliary system
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• mice injected with tamoxifen and fed the CDE-diet show reduced proportion of GITRL+Sox9+ and EpCAM+Sox9+ liver progenitor cells among the CD45- liver nonparenchymal cells
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hematopoietic system
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• mice injected with tamoxifen and fed the CDE-diet show a reduction in the proportion of liver-infiltrating CD8+ T lymphocytes and glucocorticoid-induced tumor necrosis factor receptor (GITR)-positive CD8+ T lymphocytes
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• mice injected with tamoxifen and fed the CDE-diet show no increase in GITR+ proportion of CD45+CD3+ T lymphocytes after a 9 week CDE diet, indicating lowered numbers of activated CD45+CD3+ T lymphocytes
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