Phenotypes associated with this allele

• Allele Symbol: Xrn1^em1Tya
• Allele Name: endonuclease-mediated mutation 1, Tadashi Yamamoto
• Allele ID: MGI:7621399
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Xrn1^em1Tya/Xrn1^em1Tya Tg(Camk2a-cre)2Gsc/0	involves: C57BL/6N * FVB/N	MGI:7621403

Genotype
MGI:7621403

cn1

• Allelic Composition: Xrn1^em1Tya/Xrn1^em1Tya; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:342928 )

♂ • in males, but not females, at 3-4 weeks of age

increased body weight ( J:342928 )

• rapidly gain weight after 5 weeks of age, with both males and females showing increased body weight by 6 weeks of age

• leptin treatment fails to decrease body weight

obese ( J:342928 )

increased body length ( J:342928 )

• at 12 weeks of age

increased liver weight ( J:342928 )

adipose tissue

increased brown adipose tissue amount ( J:342928 )

increased white adipose tissue amount ( J:342928 )

• increase in inguinal and epididymal white adipose tissue weight

increased white fat cell size ( J:342928 )

• drastically enlarged in inguinal and epididymal white adipose tissue

increased epididymal fat pad weight ( J:342928 )

increased inguinal fat pad weight ( J:342928 )

abnormal brown adipose tissue thermogenesis ( J:342928 )

• reduced expression of Ucp1 indicates impaired lipid metabolism

homeostasis/metabolism

increased circulating glucose level ( J:342928 )

• at 13 weeks of age but not at 5 or 6 weeks of age in males

• fed and fasting glucose levels are increased in mice at 9 weeks of age

increased circulating insulin level ( J:342928 )

♂ • at 14 weeks of age

increased circulating leptin level ( J:342928 )

♂ • at 5 weeks of age before the onset of obesity

♂ • also increased at 15 weeks of age

increased respiratory quotient ( J:342928 )

♂ • at 6 weeks of age an increase in the respiratory exchange ratio but little change in overall energy expenditure

impaired glucose tolerance ( J:342928 )

• at 5 weeks of age

insulin resistance ( J:342928 )

• at 5 weeks of age

decreased response to leptin ( J:342928 )

• leptin treatment fails to decrease food intake

abnormal lipid metabolism ( J:342928 )

♂ • the respiratory exchange ratio remains constant around 1.0 indicating that only carbohydrates are used as an energy source

behavior/neurological

increased food intake ( J:342928 )

• in males and females over 6 weeks of age

abnormal locomotor behavior ( J:342928 )

♂ • no difference in home cage activity at 12 weeks of age

nervous system

decreased brain weight ( J:342928 )

abnormal hypothalamus physiology ( J:342928 )

• upregulation of appetite and energy-homeostasis related genes at 14 weeks of age

liver/biliary system

abnormal liver morphology ( J:342928 )

• lipid accumulation

increased liver weight ( J:342928 )