Phenotypes associated with this allele

• Allele Symbol: Ccl4^em1Narl
• Allele Name: endonuclease-mediated mutation 1, National Laboratory Animal Center
• Allele ID: MGI:7621875
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl4^em1Narl/Ccl4^em1Narl	C57BL/6JNarl-Ccl4^em1Narl	MGI:7622058

Genotype
MGI:7622058

hm1

• Allelic Composition: Ccl4^em1Narl/Ccl4^em1Narl
• Genetic Background: C57BL/6JNarl-Ccl4^em1Narl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:346348 )

• mice that undergo left nephrectomy and that are injected with streptozotocin (STZ) to induce diabetic kidney disease (mutant diabetic kidney disease mice) exhibit improved renal function and decreased renal glomerulosclerosis and fibrosis

• mutant diabetic kidney disease mice show reduced levels of TNF-alpha, IL-6, and TGF-beta in the kidneys, indicating decreased renal inflammation

• blood sugar levels are reduced in mutant diabetic kidney disease mice compared to wild-type mice with diabetic kidney disease

• the kidney-to-body weight ratios are improved, serum BUN and creatinine levels are lower, urinary ACR levels are reduced, mesangial regions are not expanded and accumulation of extracellular matrix is reduced

• podocytes show less high glucose-induced inflammation and fibrosis compared to those from wild-type mice

decreased inflammatory response ( J:346348 )

• mutant diabetic kidney disease mice show reduced levels of TNF-alpha, IL-6, and TGF-beta in the kidneys, indicating decreased renal inflammation

• podocytes cultured in high-glucose medium show reduced protein expression levels of MIP-1beta, TNF-alpha, IL-6, and TGF-beta