Analysis Tools
homeostasis/metabolism
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• male mice fed a high sucrose diet or a high fat diet exhibit reduction in ALT levels
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• male mice fed ad lib chow diet show reduced liver phospholipids
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• male mice fed ad lib chow diet show reduced liver triglycerides
• however, mice fed a high sucrose diet or a high fat diet do not show any difference in liver triglyceride levels
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liver/biliary system
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• feeding a high fat/high fructose diet (HFHFD) for 35 weeks to induce nonalcoholic steatohepatitis/non-alcoholic fatty liver disease (NASH/NAFLD), does not affect body weight gain, body composition, liver enzymes, and has no effect on serum and liver lipids, and no differences in liver inflammation or fibrosis, or in liver lipid droplet size and distribution
• feeding a choline-deficient L-amino acid defined high fat diet (CDAA-HFD) for 18 weeks to induce NASH/NAFLD does not affect body weight gain, body composition, liver lipid accumulation, hepatic inflammation, fibrosis, or any changes in serum lipid levels
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• male mice fed ad lib chow diet show reduced liver phospholipids
• however, no changes in serum liver injury markers (ALT and AST) are seen
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• male mice fed ad lib chow diet show reduced liver triglycerides
• however, mice fed a high sucrose diet or a high fat diet do not show any difference in liver triglyceride levels
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