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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Magea4em1Prp
endonuclease-mediated mutation 1, Patrick Ryan Potts
MGI:7624339
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Magea10em1PrpMagea4em1Prp/Y involves: C57BL/6 MGI:7624352
cx2
 		Del(XMagea6-Magea1)1PrpMagea10em1PrpMagea4em1Prp/Y involves: C57BL/6 MGI:7624353


Genotype
MGI:7624352
cx1
Allelic
Composition		 Magea10em1PrpMagea4em1Prp/Y
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magea10em1Prp mutation (0 available); any Magea10 mutation (4 available)
Magea4em1Prp mutation (0 available); any Magea4 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:342299 )
• no defects in male fertility are detected under normal conditions

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:342299 )
N
• recovery of testis weight, seminiferous tubule morphology, and fertility after exposure to busulfan is similar to controls




Genotype
MGI:7624353
cx2
Allelic
Composition		 Del(XMagea6-Magea1)1PrpMagea10em1PrpMagea4em1Prp/Y
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(XMagea6-Magea1)1Prp mutation (0 available); any Del(XMagea6-Magea1)1Prp mutation (0 available)
Magea10em1Prp mutation (0 available); any Magea10 mutation (4 available)
Magea4em1Prp mutation (0 available); any Magea4 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:342299 )
• no defects in male fertility are detected under normal conditions
abnormal seminiferous tubule morphology ( J:342299 )
• increased damage to seminiferous tubules at 8 weeks after busulfan treatment
decreased testis weight ( J:342299 )
• at 8 weeks after busulfan treatment
reduced male fertility ( J:342299 )
• at 8 weeks after busulfan treatment
• however, fertility is similar to controls under standard conditions

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:342299 )
• decreased testis weight, increased damage to seminiferous tubules, and reduced fertility at 8 weeks after busulfan treatment
• recovery deficit is similar to mice carrying the deletion allele but wild-type for Magea10 and Magea4

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:342299 )
• increased damage to seminiferous tubules at 8 weeks after busulfan treatment
decreased testis weight ( J:342299 )
• at 8 weeks after busulfan treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory