Analysis Tools
behavior/neurological
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• both males and females show reduced duration of loss of righting response induced by ethanol, gaboxadol or zolpidem
• however, loss of righting response duration in response to ketamine is not altered
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• males, but not females, show a reduction in two-bottle choice every-other-day ethanol drinking, specifically with 15% v/v ethanol
• however, no change in ethanol consumption or preference is seen in either sex at 20% v/v ethanol and no changes in ethanol drinking behavior are seen when a continuous access, two-bottle choice assay is used sequentially increasing ethanol concentrations of 3%-18%
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• the ethanol-induced loss of righting response time is reduced in both males and females
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• while mice develop a similar low level of tolerance in response to the 1st and 2nd sedative/hypnotic ethanol doses, mice show a near unchanged ethanol-induced loss of righting response time after chronic administration of ethanol from the 1st injection of ethanol to the 2nd injection compared to controls that develop a strong ethanol tolerance, suggesting an insensitivity to repeated alcohol exposure and indicating either heightened innate tolerance or lack of tolerance induction
• however, no differences in ethanol-induced rotarod ataxia, anxiety-like bhavior, locomotion, or depressive-like behavior are seen
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nervous system
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• average mIPSC decay time is reduced in neurons of the nucleus accumbens shell of males
• males have a greater proportion of fast-decaying mIPSCs and a smaller proportion of slow-decaying mIPSCs compared to controls
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• GABA(A) receptor-mediated miniature inhibitory postsynaptic current (mIPSC) frequency is increased in neurons of the nucleus accumbens shell of males
• however, mIPSC amplitude is not affected
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