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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnt1em1Lekk
endonuclease-mediated mutation 1, Leonard K Kaczmarek
MGI:7624374
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnt1em1Lekk/Kcnt1em1Lekk C57BL/6J-Kcnt1em1Lekk MGI:7624382
ht2
 		Kcnt1em1Lekk/Kcnt1+ C57BL/6J-Kcnt1em1Lekk MGI:7624379


Genotype
MGI:7624382
hm1
Allelic
Composition		 Kcnt1em1Lekk/Kcnt1em1Lekk
Genetic
Background		 C57BL/6J-Kcnt1em1Lekk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1em1Lekk mutation (0 available); any Kcnt1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7624379
ht2
Allelic
Composition		 Kcnt1em1Lekk/Kcnt1+
Genetic
Background		 C57BL/6J-Kcnt1em1Lekk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1em1Lekk mutation (0 available); any Kcnt1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:287751 )
N
• normal behavior in open field test
seizures ( J:287751 )
• spontaneous electrographic seizures and persistent interictal spikes
increased susceptibility to pharmacologically induced seizures ( J:287751 )
• convulsive (phase 3) seizures after PTZ administration

nervous system
seizures ( J:287751 )
• spontaneous electrographic seizures and persistent interictal spikes
increased susceptibility to pharmacologically induced seizures ( J:287751 )
• convulsive (phase 3) seizures after PTZ administration

mortality/aging
mortality/aging ( J:287751 )
N
• normal survival

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
developmental and epileptic encephalopathy 14 DOID:0080439 OMIM:614959
 J:287751




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory