Phenotypes associated with this allele

• Allele Symbol: 3930402G23Rik^em1.1Gonz
• Allele Name: endonuclease-mediated mutation 1.1, Frank J Gonzalez
• Allele ID: MGI:7624488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	3930402G23Rik^em1.1Gonz/3930402G23Rik^em1.1Gonz	C57BL/6J-3930402G23Rik^em1.1Gonz	MGI:7624492

Genotype
MGI:7624492

hm1

• Allelic Composition: 3930402G23Rik^em1.1Gonz/3930402G23Rik^em1.1Gonz
• Genetic Background: C57BL/6J-3930402G23Rik^em1.1Gonz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal liver morphology ( J:340239 )

• mice fasted for 24 hours show accumulation of diacylglyceride, triglyceride, and phosphocholine in the liver compared fasted wild-type mice

• however, mice fasted for 24 hours show normal liver index, body weight loss, serum ALT and AST levels, serum total cholesterol and triglyceride levels, and serum non-esterified fatty acid levels

• treatment with a PPARalpha agonist, WY14643, to induce pharmacological stress results in the same level of hepatomegaly and decreased triglyceride and cholesterol levels in the liver as in wild-type treated mice

increased liver cholesterol level ( J:340239 )

• mice fasted for 24 hours show elevated hepatic levels of cholesterol

increased liver free fatty acids level ( J:340239 )

• mice fasted for 24 hours show elevated hepatic levels of non-esterified fatty acids

increased liver triglyceride level ( J:340239 )

• mice fasted for 24 hours show elevated hepatic triglyceride levels

increased susceptibility to hepatic steatosis ( J:340239 )

• mice fasted for 24 hours show more widespread liver lipid droplet accumulation than fasting wild-type mice

homeostasis/metabolism

increased liver cholesterol level ( J:340239 )

• mice fasted for 24 hours show elevated hepatic levels of cholesterol

increased liver free fatty acids level ( J:340239 )

• mice fasted for 24 hours show elevated hepatic levels of non-esterified fatty acids

increased liver triglyceride level ( J:340239 )

• mice fasted for 24 hours show elevated hepatic triglyceride levels