Phenotypes associated with this allele

• Allele Symbol: Tg(PRSS1/lacZ)#Gwzh
• Allele Name: transgene insertion, Guo-wei Zhang
• Allele ID: MGI:7625683
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	St13^em1Gwzh/St13^em1Gwzh Tg(PRSS1/lacZ)#Gwzh/0	Not Specified	MGI:7628221
tg2	Tg(PRSS1/lacZ)#Gwzh/0	Not Specified	MGI:7628219

Genotype
MGI:7628221

cx1

• Allelic Composition: St13^em1Gwzh/St13^em1Gwzh; Tg(PRSS1/lacZ)#Gwzh/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased susceptibility to induced pancreatitis ( J:345508 )

• mice treated with ethanol to induce alcoholic chronic pancreatitis (ACP) or caerulein to induce nonalcoholic chronic pancreatitis (nACP) exhibit more acinar cell loss, fibrosis (collagen I deposition), and fat deposition in the pancreas than in single Tg(PRSS1/lacZ)#Gwzh/0 mice and this increases over time

• mice with induced ACP or nACP show greater increases in levels of inflammatory IL-1beta, IL-6, and TNF-alpha in pancreatic tissues than in single Tg(PRSS1/lacZ)#Gwzh/0 mice

homeostasis/metabolism

abnormal lipid metabolism ( J:345508 )

• mice with induced ACP or nACP show elevated lipid metabolism in pancreatic tissue, with greater increases in levels of palmitic acid, heptadecanoic acid, stearic acid, and oleic acid (fatty acids) than in single Tg(PRSS1/lacZ)#Gwzh/0 mice

immune system

increased susceptibility to induced pancreatitis ( J:345508 )

• mice treated with ethanol to induce alcoholic chronic pancreatitis (ACP) or caerulein to induce nonalcoholic chronic pancreatitis (nACP) exhibit more acinar cell loss, fibrosis (collagen I deposition), and fat deposition in the pancreas than in single Tg(PRSS1/lacZ)#Gwzh/0 mice and this increases over time

• mice with induced ACP or nACP show greater increases in levels of inflammatory IL-1beta, IL-6, and TNF-alpha in pancreatic tissues than in single Tg(PRSS1/lacZ)#Gwzh/0 mice

Genotype
MGI:7628219

tg2

• Allelic Composition: Tg(PRSS1/lacZ)#Gwzh/0
• Genetic Background: Not Specified

immune system

increased susceptibility to induced pancreatitis ( J:345508 )

• mice treated with caerulein to induce nonalcoholic chronic pancreatitis (nACP) show elevated pancreatic acinar steatosis, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha

• mice treated with alcohol to induce alcoholic chronic pancreatitis (ACP) show a greater elevation in pancreatic acinar steatosis than mice just treated with caerulein to induce nACP

• mice with induced ACP show elevated lipid metabolism in pancreatic tissue, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha

• mice treated with parecoxib, a COX-2 inhibitor, before chronic pancreatitis induction with either caerulein or ethanol show protection against acinar injury

endocrine/exocrine glands

abnormal pancreatic acinus morphology ( J:345508 )

• mice with induced ACP show acinar steatosis, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells

abnormal pancreatic acinar cell physiology ( J:345508 )

• primary acinar cells treated with caerulein or ethanol show decreased viability

• treatment of primary acinar cells treated with caerulein or ethanol with valdecoxib ameliorates the decreased cell viability

increased susceptibility to induced pancreatitis ( J:345508 )

• mice treated with caerulein to induce nonalcoholic chronic pancreatitis (nACP) show elevated pancreatic acinar steatosis, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha

• mice treated with alcohol to induce alcoholic chronic pancreatitis (ACP) show a greater elevation in pancreatic acinar steatosis than mice just treated with caerulein to induce nACP

• mice with induced ACP show elevated lipid metabolism in pancreatic tissue, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha

• mice treated with parecoxib, a COX-2 inhibitor, before chronic pancreatitis induction with either caerulein or ethanol show protection against acinar injury

homeostasis/metabolism

abnormal lipid metabolism ( J:345508 )

• mice with induced ACP show elevated lipid metabolism in pancreatic tissue, with increased levels of palmitic acid, heptadecanoic acid, stearic acid, and oleic acid (fatty acids) and increased levels of three phospholipid pathway-related metabolites, triglyceride, diglyceride, and cholesterol

digestive/alimentary system

abnormal pancreatic acinus morphology ( J:345508 )

• mice with induced ACP show acinar steatosis, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells

abnormal pancreatic acinar cell physiology ( J:345508 )

• primary acinar cells treated with caerulein or ethanol show decreased viability

• treatment of primary acinar cells treated with caerulein or ethanol with valdecoxib ameliorates the decreased cell viability