Phenotypes associated with this allele

• Allele Symbol: St13^em1Gwzh
• Allele Name: endonuclease-mediated mutation 1, Guo-wei Zhang
• Allele ID: MGI:7625701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	St13^em1Gwzh/St13^em1Gwzh Tg(PRSS1/lacZ)#Gwzh/0	Not Specified	MGI:7628221

Genotype
MGI:7628221

cx1

• Allelic Composition: St13^em1Gwzh/St13^em1Gwzh; Tg(PRSS1/lacZ)#Gwzh/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased susceptibility to induced pancreatitis ( J:345508 )

• mice treated with ethanol to induce alcoholic chronic pancreatitis (ACP) or caerulein to induce nonalcoholic chronic pancreatitis (nACP) exhibit more acinar cell loss, fibrosis (collagen I deposition), and fat deposition in the pancreas than in single Tg(PRSS1/lacZ)#Gwzh/0 mice and this increases over time

• mice with induced ACP or nACP show greater increases in levels of inflammatory IL-1beta, IL-6, and TNF-alpha in pancreatic tissues than in single Tg(PRSS1/lacZ)#Gwzh/0 mice

homeostasis/metabolism

abnormal lipid metabolism ( J:345508 )

• mice with induced ACP or nACP show elevated lipid metabolism in pancreatic tissue, with greater increases in levels of palmitic acid, heptadecanoic acid, stearic acid, and oleic acid (fatty acids) than in single Tg(PRSS1/lacZ)#Gwzh/0 mice

immune system

increased susceptibility to induced pancreatitis ( J:345508 )

• mice treated with ethanol to induce alcoholic chronic pancreatitis (ACP) or caerulein to induce nonalcoholic chronic pancreatitis (nACP) exhibit more acinar cell loss, fibrosis (collagen I deposition), and fat deposition in the pancreas than in single Tg(PRSS1/lacZ)#Gwzh/0 mice and this increases over time

• mice with induced ACP or nACP show greater increases in levels of inflammatory IL-1beta, IL-6, and TNF-alpha in pancreatic tissues than in single Tg(PRSS1/lacZ)#Gwzh/0 mice