Phenotypes associated with this allele

• Allele Symbol: Igsf3^em1Laap
• Allele Name: endonuclease-mediated mutation 1, Pirjo Laakkonen
• Allele ID: MGI:7626255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igsf3^em1Laap/Igsf3^em1Laap	FVB/NRj-Igsf3^em1Laap	MGI:7626285

Genotype
MGI:7626285

hm1

• Allelic Composition: Igsf3^em1Laap/Igsf3^em1Laap
• Genetic Background: FVB/NRj-Igsf3^em1Laap

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal vagal neural crest cell migration ( J:341537 )

• migration length of vagal neural crest cell explants from E9 embryos on fibronectin-coated plates is reduced

• however, no difference in the migration of trunk neural crest cells in culture is seen

digestive/alimentary system

abnormal intestinal smooth muscle morphology ( J:341537 )

• small intestine shows disorganized structure with rudimentary outer muscle layer at P9

• the proximal small intestine at P12.5 shows reduced thickness of the muscularis externa indicating impaired development of the intestinal muscularis propria

abnormal small intestinal villus morphology ( J:341537 )

• intestinal villi show a reduced number of nerve fibers per villi

• however, no difference in the muscle fiber counts per villi is seen

• mice show disorganization of the small intestinal villi, with impaired alignment of neurons with the smooth muscle cells in the developing intestinal villi indicating disorganized innervation of the enteric villi

nervous system

abnormal enteric nervous system morphology ( J:341537 )

• development of the enteric nervous system in the small intestine is impaired

abnormal enteric neuron morphology ( J:341537 )

• intestinal villi show a reduced number of nerve fibers per villi

abnormal innervation ( J:341537 )

• intestinal villi show a reduced number of nerve fibers per villi with no difference in the muscle fiber counts per villi, and impaired alignment of neurons with the smooth muscle in the intestine indicating that proper development and organization of the innervation process of the intestinal villi is impaired

embryo

abnormal vagal neural crest cell migration ( J:341537 )

• migration length of vagal neural crest cell explants from E9 embryos on fibronectin-coated plates is reduced

• however, no difference in the migration of trunk neural crest cells in culture is seen

muscle

abnormal intestinal smooth muscle morphology ( J:341537 )

• small intestine shows disorganized structure with rudimentary outer muscle layer at P9

• the proximal small intestine at P12.5 shows reduced thickness of the muscularis externa indicating impaired development of the intestinal muscularis propria