Phenotypes associated with this allele

• Allele Symbol: Tbc1d15^em1Jren
• Allele Name: endonuclease-mediated mutation 1, Jun Ren
• Allele ID: MGI:7626319
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tbc1d15^em1Jren/Tbc1d15^em1Jren A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: C57BL/6N * FVB/N	MGI:7645414

Genotype
MGI:7645414

cn1

• Allelic Composition: Tbc1d15^em1Jren/Tbc1d15^em1Jren; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased susceptibility to myocardial ischemic injury ( J:341775 )

♂ • cardiac dysfunction is increased following ischemia/reperfusion injury

♂ • increase in adverse cardiac remodeling (interstitial fibrosis) following ischemia/reperfusion injury

♂ • increase in mitochondrial damage following ischemia/reperfusion injury

increased myocardial infarct size ( J:341775 )

♂ • following ischemia/reperfusion injury

cellular

abnormal intracellular organelle morphology ( J:341775 )

♂ • decreased distance and increased length of mitochondria-lysosome contacts

abnormal mitochondrial physiology ( J:341775 )

♂ • increased susceptibility to ischemia/reperfusion induced injury in cardiac cells

♂ • ischemia/reperfusion induced increase in tethering of mitochondria and lysosomes is exacerbated

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:341775 )

♂ • cardiac dysfunction is increased following ischemia/reperfusion injury

♂ • increase in adverse cardiac remodeling (interstitial fibrosis) following ischemia/reperfusion injury

♂ • increase in mitochondrial damage following ischemia/reperfusion injury

increased myocardial infarct size ( J:341775 )

♂ • following ischemia/reperfusion injury