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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp4em1Pwa
endonuclease-mediated mutation 1, Ping Wang
MGI:7627086
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp4em1Pwa/Usp4em1Pwa Not Specified MGI:7627087


Genotype
MGI:7627087
hm1
Allelic
Composition		 Usp4em1Pwa/Usp4em1Pwa
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp4em1Pwa mutation (0 available); any Usp4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:298778 )
• in a model of colitis-associated colorectal tumorigenesis (azoxymethane followed by 3 rounds of DSS treatment) mice develop fewer tumors and reduced body weight loss compared to wild-type controls

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:298778 )
• in a model of colitis-associated colorectal tumorigenesis (azoxymethane followed by 3 rounds of DSS treatment) mice develop fewer tumors and reduced body weight loss compared to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory