Phenotypes associated with this allele

• Allele Symbol: Ttc39aos1^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:7627138
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttc39aos1^em1Bcgen/Ttc39aos1^em1Bcgen	involves: C57BL/6N	MGI:7627148

Genotype
MGI:7627148

hm1

• Allelic Composition: Ttc39aos1^em1Bcgen/Ttc39aos1^em1Bcgen
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased susceptibility to induced pancreatitis ( J:307097 )

• more severe symptoms (edema, leukocyte infiltration, tissue necrosis) in caerulein-induced and sodium taurocholate-induced acute pancreatitis

• do not develop spontaneous pancreatitis

• more severe systemic inflammatory response syndrome (SIRS) in sodium taurocholate-induced acute pancreatitis with lung and liver damage and increased gut permeability

homeostasis/metabolism

increased cytokine level ( J:307097 )

• increased induction of cytokines in induced acute pancreatitis models

immune system

increased susceptibility to induced pancreatitis ( J:307097 )

• more severe symptoms (edema, leukocyte infiltration, tissue necrosis) in caerulein-induced and sodium taurocholate-induced acute pancreatitis

• do not develop spontaneous pancreatitis

• more severe systemic inflammatory response syndrome (SIRS) in sodium taurocholate-induced acute pancreatitis with lung and liver damage and increased gut permeability

increased cytokine level ( J:307097 )

• increased induction of cytokines in induced acute pancreatitis models