Phenotypes associated with this allele

• Allele Symbol: Ighg2c^em2Wliu
• Allele Name: endonuclease-mediated mutation 2, Wanli Liu
• Allele ID: MGI:7627371
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighg2c^em2Wliu/Ighg2c^em2Wliu	C57BL/6J-Ighg2c^em2Wliu	MGI:7738837

Genotype
MGI:7738837

hm1

• Allelic Composition: Ighg2c^em2Wliu/Ighg2c^em2Wliu
• Genetic Background: C57BL/6J-Ighg2c^em2Wliu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor growth/size ( J:322180 )

• in a B16-mOVA tumor cell intravenous transplantation model, mice exhibit increased tumor volume, weight and growth compared to wild-type mice

• tumor growth is exacerbated during the subsequent MC38-mOVA challenge

immune system

impaired macrophage phagocytosis ( J:322180 )

• IgG purified from OVA-immunized mice with MC38-mOVA induction shows less potent bone marrow derived macrophage activation and phagocytosis of antibody-targeted tumor cells

abnormal plasma cell differentiation ( J:322180 )

• in an OVA antigen-based immunization model, mice show a decrease in OVA-specific IgG2c+ plasma cells in the bone marrow and spleen in the tumor microenvironment

decreased germinal center B cell number ( J:322180 )

• in an ovalbumin (OVA) antigen-based immunization model, mice show lower percentage of OVA-specific IgG2c+ germinal center B cells in the spleen in the tumor microenvironment

decreased memory B cell number ( J:322180 )

• in an ovalbumin (OVA) antigen-based immunization model, mice show a decrease in OVA-specific IgG2c+ memory B cells in the spleen and bone marrow, indicating a reduction of class-switched memory B cells in the tumor microenvironment

decreased IgG2c level ( J:322180 )

• after immunization of OVA antigen combined with Th1-prone adjuvant, OVA-specific IgG2c antibody production is decreased in serum

abnormal macrophage activation involved in immune response ( J:322180 )

• IgG purified from OVA-immunized mice with MC38-mOVA induction shows less potent bone marrow derived macrophage activation and phagocytosis of antibody-targeted tumor cells

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:322180 )

• in the B16-mOVA tumor cell intravenous transplantation model, mice exhibit reduced survival compared with wild-type mice

cellular

impaired macrophage phagocytosis ( J:322180 )

• IgG purified from OVA-immunized mice with MC38-mOVA induction shows less potent bone marrow derived macrophage activation and phagocytosis of antibody-targeted tumor cells

hematopoietic system

impaired macrophage phagocytosis ( J:322180 )

• IgG purified from OVA-immunized mice with MC38-mOVA induction shows less potent bone marrow derived macrophage activation and phagocytosis of antibody-targeted tumor cells

abnormal plasma cell differentiation ( J:322180 )

• in an OVA antigen-based immunization model, mice show a decrease in OVA-specific IgG2c+ plasma cells in the bone marrow and spleen in the tumor microenvironment

decreased germinal center B cell number ( J:322180 )

• in an ovalbumin (OVA) antigen-based immunization model, mice show lower percentage of OVA-specific IgG2c+ germinal center B cells in the spleen in the tumor microenvironment

decreased memory B cell number ( J:322180 )

• in an ovalbumin (OVA) antigen-based immunization model, mice show a decrease in OVA-specific IgG2c+ memory B cells in the spleen and bone marrow, indicating a reduction of class-switched memory B cells in the tumor microenvironment

decreased IgG2c level ( J:322180 )

• after immunization of OVA antigen combined with Th1-prone adjuvant, OVA-specific IgG2c antibody production is decreased in serum

abnormal macrophage activation involved in immune response ( J:322180 )

• IgG purified from OVA-immunized mice with MC38-mOVA induction shows less potent bone marrow derived macrophage activation and phagocytosis of antibody-targeted tumor cells