Phenotypes associated with this allele

• Allele Symbol: Tcf25^em1Xdzg
• Allele Name: endonuclease-mediated mutation 1, Xiao-Dong Zhang
• Allele ID: MGI:7628233
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf25^em1Xdzg/Tcf25^em1Xdzg	involves: C57BL/6J	MGI:7639758

Genotype
MGI:7639758

hm1

• Allelic Composition: Tcf25^em1Xdzg/Tcf25^em1Xdzg
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased response of heart to induced stress ( J:317382 )

• exacerbated aortic banding induced cardiac hypertrophy with significantly greater heart weight gain at 4 weeks after surgery

• increase in post-aortic banding myocardial fibrosis

• treatment with the NFAT inhibitor VIVIT blocks the exacerbation of aortic banding induced cardiac hypertrophy

• no morphological differences are detected in untreated mice

homeostasis/metabolism

increased response of heart to induced stress ( J:317382 )

• exacerbated aortic banding induced cardiac hypertrophy with significantly greater heart weight gain at 4 weeks after surgery

• increase in post-aortic banding myocardial fibrosis

• treatment with the NFAT inhibitor VIVIT blocks the exacerbation of aortic banding induced cardiac hypertrophy

• no morphological differences are detected in untreated mice