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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thbs4tm1Olsa
targeted mutation 1, Olga Stenina-Adognravi
MGI:7628361
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Thbs4tm1Olsa/Thbs4tm1Olsa C57BL/6J-Thbs4tm1Olsa MGI:7628705
cx2
 		Apoetm1Unc/Apoetm1Unc
Thbs4tm1Olsa/Thbs4tm1Olsa 		involves: 129P2/OlaHsd * C57BL/6J MGI:7628726


Genotype
MGI:7628705
hm1
Allelic
Composition		 Thbs4tm1Olsa/Thbs4tm1Olsa
Genetic
Background		 C57BL/6J-Thbs4tm1Olsa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thbs4tm1Olsa mutation (0 available); any Thbs4 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:301049 )
N
• normal number of monocytes in blood after LPS-induced peritonitis
decreased macrophage cell number ( J:301049 )
• in peritoneal tissues after LPS-induced peritonitis
• reduced number of macrophages collected by peritoneal lavage after LPS-induced peritonitis

cardiovascular system
abnormal retina vasculature morphology ( J:301119 )
• more retinal vasculature at age P5 with more branchpoints

immune system
decreased macrophage cell number ( J:301049 )
• in peritoneal tissues after LPS-induced peritonitis
• reduced number of macrophages collected by peritoneal lavage after LPS-induced peritonitis

homeostasis/metabolism
enhanced wound healing ( J:301119 )
• significantly smaller wound 5 days post-wounding

vision/eye
abnormal retina vasculature morphology ( J:301119 )
• more retinal vasculature at age P5 with more branchpoints




Genotype
MGI:7628726
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Thbs4tm1Olsa/Thbs4tm1Olsa
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Thbs4tm1Olsa mutation (0 available); any Thbs4 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased macrophage cell number ( J:345752 )
• in atherosclerotic lesions when fed western diet
• increased CD38+ pro-inflammatory macrophages in atherosclerotic lesions when fed western diet

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:345752 )
N
• normal plasma LDL/VLDL and HDL levels when fed either western diet or regular chow
increased cholesterol level ( J:345752 )
• normal when fed regular chow
• increased free and total cholesterol levels when fed western diet
increased chemokine level ( J:345752 )
• increased plasma CXCL1 and CCL2 levels when fed western diet

immune system
increased macrophage cell number ( J:345752 )
• in atherosclerotic lesions when fed western diet
• increased CD38+ pro-inflammatory macrophages in atherosclerotic lesions when fed western diet
increased chemokine level ( J:345752 )
• increased plasma CXCL1 and CCL2 levels when fed western diet




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory