Phenotypes associated with this allele

• Allele Symbol: Fbxo24^em1Syu
• Allele Name: endonuclease-mediated mutation 1, Shuiqiao Yuan
• Allele ID: MGI:7628680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxo24^em1Syu/Fbxo24^em1Syu	involves: C57BL/6J	MGI:7628683

Genotype
MGI:7628683

hm1

• Allelic Composition: Fbxo24^em1Syu/Fbxo24^em1Syu
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:347878 )

♂N • testes size and weight are similar to controls

abnormal sperm flagellum morphology ( J:347878 )

♂ • abnormal bending of the flagella

abnormal sperm axoneme morphology ( J:347878 )

♂ • incomplete axonemes with missing axonemal microtubules

abnormal sperm midpiece morphology ( J:347878 )

♂ • gap in the midpiece

♂ • length of the midpiece is decreased

abnormal sperm mitochondrial sheath morphology ( J:347878 )

♂ • mitochondria are absent near the annulus or neck leaving gaps in the sheath

disorganized sperm mitochondrial sheath ( J:347878 )

♂

abnormal sperm fibrous sheath morphology ( J:347878 )

♂ • partial or complete absence of outer dense fibers

abnormal sperm head morphology ( J:347878 )

♂ • abnormal head shape

♂ • absence of the distinct equatorial segment, post-acrosomal sheath, ventral spur, and sharp hook rim

abnormal acrosome morphology ( J:347878 )

♂ • disorganized anterior acrosome

abnormal sperm nucleus morphology ( J:347878 )

♂ • less condensed with increased levels of all core histones

abnormal chromatoid body morphology ( J:347878 )

• increased size of chromatoid bodies in spermatids

abnormal spermatid morphology ( J:347878 )

♂ • decreased number of elongated spermatids, condensing spermatids, and condensed spermatids

♂ • increased size of chromatoid bodies

decreased male germ cell number ( J:347878 )

♂ • decreased number of elongated spermatids, condensing spermatids, and condensed spermatids

oligozoospermia ( J:347878 )

♂

asthenozoospermia ( J:347878 )

♂

abnormal male germ cell physiology ( J:347878 )

♂ • abnormal mRNA splicing in round spermatids

♂ • increase in piRNA production in the testes

increased male germ cell apoptosis ( J:347878 )

♂ • increase in apoptotic signals in late spermatids

male infertility ( J:347878 )

♂ • males, but not females, are infertile

cellular

abnormal sperm flagellum morphology ( J:347878 )

♂ • abnormal bending of the flagella

abnormal sperm axoneme morphology ( J:347878 )

♂ • incomplete axonemes with missing axonemal microtubules

abnormal sperm midpiece morphology ( J:347878 )

♂ • gap in the midpiece

♂ • length of the midpiece is decreased

abnormal sperm mitochondrial sheath morphology ( J:347878 )

♂ • mitochondria are absent near the annulus or neck leaving gaps in the sheath

disorganized sperm mitochondrial sheath ( J:347878 )

♂

abnormal sperm fibrous sheath morphology ( J:347878 )

♂ • partial or complete absence of outer dense fibers

abnormal sperm head morphology ( J:347878 )

♂ • abnormal head shape

♂ • absence of the distinct equatorial segment, post-acrosomal sheath, ventral spur, and sharp hook rim

abnormal acrosome morphology ( J:347878 )

♂ • disorganized anterior acrosome

abnormal sperm nucleus morphology ( J:347878 )

♂ • less condensed with increased levels of all core histones

abnormal chromatoid body morphology ( J:347878 )

• increased size of chromatoid bodies in spermatids

abnormal spermatid morphology ( J:347878 )

♂ • decreased number of elongated spermatids, condensing spermatids, and condensed spermatids

♂ • increased size of chromatoid bodies

decreased male germ cell number ( J:347878 )

♂ • decreased number of elongated spermatids, condensing spermatids, and condensed spermatids

oligozoospermia ( J:347878 )

♂

abnormal mitochondrial morphology ( J:347878 )

♂ • spermatids have swollen mitochondria with abnormal central cristae

abnormal mitochondrial crista morphology ( J:347878 )

♂ • in spermatids

asthenozoospermia ( J:347878 )

♂

abnormal male germ cell physiology ( J:347878 )

♂ • abnormal mRNA splicing in round spermatids

♂ • increase in piRNA production in the testes

increased male germ cell apoptosis ( J:347878 )

♂ • increase in apoptotic signals in late spermatids