About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		rd22
retinal degeneration 22
MGI:7638770
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		rd22/rd22 B6.Cg-rd22/BocJ MGI:7640026


Genotype
MGI:7640026
hm1
Allelic
Composition		 rd22/rd22
Genetic
Background		 B6.Cg-rd22/BocJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
rd22 mutation (1 available); any rd22 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:347903 )
N
• no sterility observed

nervous system
retina cone cell degeneration ( J:347903 )
• histology shows significant loss of cone photoreceptors by 2 months of age
abnormal retina rod cell morphology ( J:347903 )
• mislocalization of rod photoreceptors to the inner nuclear layer

cardiovascular system
abnormal retina blood vessel morphology ( J:347903 )
• vessel attenuation evident at 1 month of age

vision/eye
abnormal retina blood vessel morphology ( J:347903 )
• vessel attenuation evident at 1 month of age
retina cone cell degeneration ( J:347903 )
• histology shows significant loss of cone photoreceptors by 2 months of age
abnormal retina rod cell morphology ( J:347903 )
• mislocalization of rod photoreceptors to the inner nuclear layer
retina degeneration ( J:347903 )
• beginning by 1 month of age. Fundus and OCT both show retinal degeneration
abnormal eye electrophysiology ( J:347903 )
• by 1 month of age no light-adapted ERG response; dark-adapted ERG responses have decreasing amplitudes with age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cone-rod dystrophy 19 DOID:0111025 OMIM:615860
 J:347903




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory