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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		rd22
retinal degeneration 22
MGI:7638770
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		rd22/rd22 B6.Cg-rd22/BocJ MGI:7640026


Genotype
MGI:7640026
hm1
Allelic
Composition		 rd22/rd22
Genetic
Background		 B6.Cg-rd22/BocJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
rd22 mutation (1 available); any rd22 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:347903 )
N
• no sterility observed

nervous system
retina cone cell degeneration ( J:347903 )
• histology shows significant loss of cone photoreceptors by 2 months of age
abnormal retina rod cell morphology ( J:347903 )
• mislocalization of rod photoreceptors to the inner nuclear layer

cardiovascular system
abnormal retina blood vessel morphology ( J:347903 )
• vessel attenuation evident at 1 month of age

vision/eye
abnormal retina blood vessel morphology ( J:347903 )
• vessel attenuation evident at 1 month of age
retina cone cell degeneration ( J:347903 )
• histology shows significant loss of cone photoreceptors by 2 months of age
abnormal retina rod cell morphology ( J:347903 )
• mislocalization of rod photoreceptors to the inner nuclear layer
retina degeneration ( J:347903 )
• beginning by 1 month of age. Fundus and OCT both show retinal degeneration
abnormal eye electrophysiology ( J:347903 )
• by 1 month of age no light-adapted ERG response; dark-adapted ERG responses have decreasing amplitudes with age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cone-rod dystrophy 19 DOID:0111025 OMIM:615860
 J:347903




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory