Phenotypes associated with this allele

• Allele Symbol: Ccdc50^em2Gpt
• Allele Name: endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
• Allele ID: MGI:7638801
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc50^em2Gpt/Ccdc50^em2Gpt	C57BL/6J-Ccdc50^em2Gpt	MGI:7639664

Genotype
MGI:7639664

hm1

• Allelic Composition: Ccdc50^em2Gpt/Ccdc50^em2Gpt
• Genetic Background: C57BL/6J-Ccdc50^em2Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:345495 )

• mice show improved survival rate after herpes simplex virus 1 (HSV-1) infection compared to wild-type mice

immune system

increased circulating interferon-beta level ( J:345495 )

• mice infected with HSV-1 show higher levels of IFN-beta in serum

increased interferon-beta secretion ( J:345495 )

• bone marrow-derived macrophages (BMDMs) and bone marrow-derived dendritic cells (BMDCs) stimulated with cGAS inducers poly(dA:dT) and HSV60 and STING agonist cGAMP show higher production and secretion of IFN-beta

decreased susceptibility to Herpesvirales infection ( J:345495 )

• mice show decreased susceptibility to HSV-1 infection, showing decreased HSV-1 replication (reduced gDNA copy number) in the brain and liver, decreased HSV-1 titers in the brain, and improved survival rate

• mice infected with HSV-1 show enhanced ability to eliminate virus and reduced inflammatory cell infiltration and tissue damage in the lung

• BMDMs and BMDCs infected with HSV-1 show reduced replication of viral gDNA and viral titers indicating suppressed viral infection in these cells

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:345495 )

• mice show improved survival rate after herpes simplex virus 1 (HSV-1) infection compared to wild-type mice

homeostasis/metabolism

increased circulating interferon-beta level ( J:345495 )

• mice infected with HSV-1 show higher levels of IFN-beta in serum

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:345495 )

N • the cell number in the thymus is normal in 6- to 8-week-old mice