Phenotypes associated with this allele

• Allele Symbol: Cdh2^tm1.1Ayki
• Allele Name: targeted mutation 1.1, Ayae Kinoshita
• Allele ID: MGI:7639718
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh2^tm1.1Ayki/Cdh2^tm1.1Ayki	involves: C57BL/6 * DBA/2	MGI:7639751

Genotype
MGI:7639751

hm1

• Allelic Composition: Cdh2^tm1.1Ayki/Cdh2^tm1.1Ayki
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced cued conditioning behavior ( J:302799 )

♂ • enhanced freezing in late phases of fear conditioning test day 1 and upon re-exposure to shock box on day 2

enhanced spatial working memory ( J:302799 )

♂ • longer initial acquisition time to reward in 8-arm radial maze but fewer revisiting errors afterwards

nervous system

nervous system phenotype ( J:302799 )

♂N • normal brain weight and gross morphology

abnormal hippocampus pyramidal cell morphology ( J:302799 )

♂ • significantly higher complexity in tufts of thorny excrescence in CA3 stratum lucidum region: increased dendrite thorny excrescence area and tuft count

♂ • significantly higher density of asymmetrical (mostly glutamatergic) synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

♂ • smaller post-synaptic density (PSD) area in synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

♂ • normal dendritic spine volume in CA3 stratum radiatum

abnormal asymmetric synapse morphology ( J:302799 )

♂ • significantly higher density of asymmetrical (mostly glutamatergic) synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

abnormal postsynaptic density morphology ( J:302799 )

♂ • smaller post-synaptic density (PSD) area in synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

abnormal CNS synaptic transmission ( J:302799 )

♂ • reduced excitatory postsynaptic potential (EPSP) slopes with higher stimulus intensities in synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

♂ • larger magnitude of LTP after high-frequency stimulation in synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

♂ • normal basal synaptic transmission and paired pulse ratio in synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

abnormal excitatory postsynaptic potential ( J:302799 )

♂ • reduced excitatory postsynaptic potential (EPSP) slopes with higher stimulus intensities in synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

enhanced long-term potentiation ( J:302799 )

♂ • larger magnitude of LTP after high-frequency stimulation in synapses between associational/commissural fibers and pyramidal neurons in CA3 stratum radiatum

reproductive system

reproductive system phenotype ( J:302799 )

♂N • fertile

growth/size/body

growth/size/body region phenotype ( J:302799 )

♂N • normal growth