Phenotypes associated with this allele

• Allele Symbol: Nfatc1^tm1.1Fbs
• Allele Name: targeted mutation 1.1, Friederike Berberich-Siebelt
• Allele ID: MGI:7639766
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfatc1^tm1.1Fbs/Nfatc1^tm1.1Fbs	C57BL/6-Nfatc1^tm1.1Fbs	MGI:7639786

Genotype
MGI:7639786

hm1

• Allelic Composition: Nfatc1^tm1.1Fbs/Nfatc1^tm1.1Fbs
• Genetic Background: C57BL/6-Nfatc1^tm1.1Fbs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:305649 )

N • normal steady-state T cell populations

N • normal activated T cell proliferation suppression

increased regulatory T cell number ( J:305649 )

• after MOG35-55induced EAE

decreased interferon-gamma secretion ( J:305649 )

• decreased number of IFNG-producing CD4+ T cells after differentiation to Th1 and Th17 cells in vitro

decreased interleukin-17 secretion ( J:305649 )

• decreased number of IL17A-producing CD4+ T cells after differentiation to Th1 and Th17 cells in vitro

increased interleukin-2 secretion ( J:305649 )

• increased number of IL2-producing CD4+ T cells after activation in vitro

• increased number of IL2-producing CD4+ T cells after differentiation to Th1 and Th17 cells in vitro

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:305649 )

• partial protection against MOG35-55induced EAE

decreased susceptibility to graft versus host disease ( J:305649 )

hematopoietic system

increased regulatory T cell number ( J:305649 )

• after MOG35-55induced EAE