Phenotypes associated with this allele

• Allele Symbol: Akr1c21^em1Wany
• Allele Name: endonuclease-mediated mutation 1, Yanli Wang
• Allele ID: MGI:7639885
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akr1c21^em1Wany/Akr1c21^em1Wany	involves: C57BL/6	MGI:7639887

Genotype
MGI:7639887

hm1

• Allelic Composition: Akr1c21^em1Wany/Akr1c21^em1Wany
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

lung inflammation ( J:322353 )

• aggravation of LPS-induced histological changes (denudation of alveolar membrane, cellular infiltration, edema formation, and hyaline membrane deposition) in the lung

immune system

increased interleukin level ( J:322353 )

• elevated levels of IL6, IL1, and TNF-alpha in the bronchoalveolar lavage fluid in LPS treated mice compared to similarly treated wild-type controls

increased acute inflammation ( J:322353 )

• following LPS treatment mice show an increase in total cell and neutrophil recruitment to the lungs compared to similarly treated wild-type controls

• elevated levels of IL6, IL1, and TNF-alpha in the bronchoalveolar lavage fluid in LPS treated mice compared to similarly treated wild-type controls

• increase in oxidative products in the lungs in LPS treated mice compared to similarly treated wild-type controls

lung inflammation ( J:322353 )

• aggravation of LPS-induced histological changes (denudation of alveolar membrane, cellular infiltration, edema formation, and hyaline membrane deposition) in the lung

homeostasis/metabolism

increased interleukin level ( J:322353 )

• elevated levels of IL6, IL1, and TNF-alpha in the bronchoalveolar lavage fluid in LPS treated mice compared to similarly treated wild-type controls

cellular

oxidative stress ( J:322353 )

• increase in oxidative products in the lungs in LPS treated mice compared to similarly treated wild-type controls