Phenotypes associated with this allele

• Allele Symbol: Mrgprx1^em1Cao
• Allele Name: endonuclease-mediated mutation 1, Zhijian Cao
• Allele ID: MGI:7639969
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrgprx1^em1Cao/Mrgprx1^em1Cao	involves: C57BL/6	MGI:7640027

Genotype
MGI:7640027

hm1

• Allelic Composition: Mrgprx1^em1Cao/Mrgprx1^em1Cao
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron physiology ( J:329699 )

• significant attenuation of oxidated IP defensin 1 (IP-O) induced Ca2+ signaling in dorsal root ganglion (DRG) neurons

• attenuation of BAM evoked responses in DRG neurons

• decrease in the percentage of IP-o or BAM sensitive DRG neurons

integument

decreased pruritus ( J:329699 )

• decreased IP-O induced scratch response