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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otub2tm1.1Gpt
targeted mutation 1, GemPharmatech Co., Ltd
MGI:7640053
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otub2tm1.1Gpt/Otub2tm1.1Gpt involves: C57BL/6JGpt MGI:7641406
ht2
 		Otub2tm1.1Gpt/Otub2+ involves: C57BL/6JGpt MGI:7641426


Genotype
MGI:7641406
hm1
Allelic
Composition		 Otub2tm1.1Gpt/Otub2tm1.1Gpt
Genetic
Background		 involves: C57BL/6JGpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otub2tm1.1Gpt mutation (0 available); any Otub2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide compared to similarly treated control mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide compared to similarly treated control mice




Genotype
MGI:7641426
ht2
Allelic
Composition		 Otub2tm1.1Gpt/Otub2+
Genetic
Background		 involves: C57BL/6JGpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otub2tm1.1Gpt mutation (0 available); any Otub2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide (4NQO) compared to similarly treated control mice
• however, incidence of 4NQO induced upper gastrointestinal squamous cell carcinomasis decreased compared to homozygous mice

neoplasm
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide (4NQO) compared to similarly treated control mice
• however, incidence of 4NQO induced upper gastrointestinal squamous cell carcinomasis decreased compared to homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory