About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otub2tm1.1Gpt
targeted mutation 1, GemPharmatech Co., Ltd
MGI:7640053
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otub2tm1.1Gpt/Otub2tm1.1Gpt involves: C57BL/6JGpt MGI:7641406
ht2
 		Otub2tm1.1Gpt/Otub2+ involves: C57BL/6JGpt MGI:7641426


Genotype
MGI:7641406
hm1
Allelic
Composition		 Otub2tm1.1Gpt/Otub2tm1.1Gpt
Genetic
Background		 involves: C57BL/6JGpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otub2tm1.1Gpt mutation (0 available); any Otub2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide compared to similarly treated control mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide compared to similarly treated control mice




Genotype
MGI:7641426
ht2
Allelic
Composition		 Otub2tm1.1Gpt/Otub2+
Genetic
Background		 involves: C57BL/6JGpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otub2tm1.1Gpt mutation (0 available); any Otub2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide (4NQO) compared to similarly treated control mice
• however, incidence of 4NQO induced upper gastrointestinal squamous cell carcinomasis decreased compared to homozygous mice

neoplasm
increased incidence of tumors by chemical induction ( J:330595 )
• increase in the incidence of upper gastrointestinal squamous cell carcinomas (tongue and esophageal tumors) following treatment with 4-nitroquinoline 1-oxide (4NQO) compared to similarly treated control mice
• however, incidence of 4NQO induced upper gastrointestinal squamous cell carcinomasis decreased compared to homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory