Analysis Tools
liver/biliary system
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• livers of male mice fed a MASH diet show decreased liver fibrosis and a reduction of the abundance of hepatic GPNMB+CD9+ NASH-associated macrophages (NAMs)
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• mice fed a metabolic dysfunction-associated steatohepatitis (MASH) diet (40 kcal % fat, 20 kcal % fructose, and 2% cholesterol) show lower plasma aspartate aminotransferase (AST) and alanine transaminase (ALT) concentrations, improved severity of liver fibrosis, and decreased plasma concentrations of the proinflammatory cytokines CCL2 and TNF-alpha and abundance of hepatic GPNMB+CD9+ NASH-associated macrophages (NAMs)
• however, mice fed a MASH diet show similar hepatic steatosis, body weight, liver weight and plasma lipids as controls
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homeostasis/metabolism
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• males fed a MASH diet show lower plasma TNF-alpha levels
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• mice fed a MASH diet show lower plasma ALT levels
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• mice fed a MASH diet show lower plasma AST levels
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• males fed a MASH diet show lower plasma CCL2 levels
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immune system
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• males fed a MASH diet show lower plasma TNF-alpha levels
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• males fed a MASH diet show lower plasma CCL2 levels
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