Phenotypes associated with this allele

• Allele Symbol: Extl1^em1Caox
• Allele Name: endonuclease-mediated mutation 1, Xuetao Cao
• Allele ID: MGI:7641465
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Extl1^em1Caox/Extl1^em1Caox Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * CBA	MGI:7641474

Genotype
MGI:7641474

cn1

• Allelic Composition: Extl1^em1Caox/Extl1^em1Caox; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:333437 )

• decreased survival time, increased lung bacterial load, and increased lung inflammation after E. coli infection

immune system

immune system phenotype ( J:333437 )

N • frequencies of major immune cell subtypes are similar to controls in 6- to 8 week old mice

enlarged spleen ( J:333437 )

• at 7-10 months of age

decreased dendritic cell number ( J:333437 )

• decrease in the proportion of CD11c+ dendritic cells in the draining lymph nodes but not in the spleen

• no abnormalities are detected in the development from precursors or survival, maturation, or T cell stimulating capacity of dendritic cells

• decrease in the proportion of CCR7+ CD11c+ cDCs but not CCR7+ CD11c- cells in draining lymph nodes under steady state conditions or after DFNB stimulation

• decreased proportions of CD11c+ cDCs and CCR7+ cDCs in the spleen and draining lymph nodes at 7-10 months of age

• decrease in the proportion of migratory but not resident cDCs in draining lymph nodes at 7-10 months of age

increased B cell number ( J:333437 )

• increased frequency of CD19+ B cells in the spleen and draining lymph nodes at 7-10 months of age

decreased T helper 1 cell number ( J:333437 )

• decreased development at 7-10 months of age

increased T cell number ( J:333437 )

• increased frequency of CD3+ T cells in spleen and draining lymph nodes at 7-10 months of age

increased T-helper 17 cell number ( J:333437 )

• increased development of Th17 cells at 7-10 months of age

increased Ly6C high monocyte number ( J:333437 )

• increased frequency of Ly6c^hiCD11c^hi monocytes in the spleen and draining lymph nodes at 7-10 months of age

abnormal regulatory T cell morphology ( J:333437 )

• impaired development of CD25+ and FOXP3+ Treg cells in draining lymph nodes but not the spleen

• impaired development of CD25+ and FOXP3+ Treg cells at 7-10 months of age

increased immunoglobulin level ( J:333437 )

• at 7-10 months of age Ig levels are increased

increased IgG level ( J:333437 )

• kidney IgG deposits at 7-10 months of age

increased circulating interleukin-17 level ( J:333437 )

• increased IL17a level at 7-10 months of age

increased circulating interleukin-6 level ( J:333437 )

• at 7-10 months of age

increased circulating tumor necrosis factor level ( J:333437 )

• at 7-10 months of age

enlarged lymph nodes ( J:333437 )

• at 7-10 months of age

abnormal dendritic cell physiology ( J:333437 )

• reduced level of basal CCR7 surface expression

abnormal dendritic cell migration ( J:333437 )

• reduced migration towards draining lymph nodes

• however, proportion of CD103+ CD11b- cDC1 and CD103- CD11b+ cDC2 in peripheral lung tissue are similar to controls

abnormal dendritic cell chemotaxis ( J:333437 )

• reduced migratory capacity in response to the ligand CCR7 but not CCL2 or CCL8 in mature dendritic cells

increased interleukin-6 secretion ( J:333437 )

• increased IL6 production in LPS stimulated mature dendritic cells

increased susceptibility to autoimmune disorder ( J:333437 )

• spontaneous development of systemic autoimmune disorders in elderly mice (7-10 months of age)

decreased acute inflammation ( J:333437 )

• reduced ear swelling following induction by 2,4-dinitro-fluorobenzene (DFNB)

chronic inflammation ( J:333437 )

• enhanced inflammatory cell infiltration in multiple organs at 7-10 months of age

increased susceptibility to bacterial infection induced morbidity/mortality ( J:333437 )

• decreased survival time, increased lung bacterial load, and increased lung inflammation after E. coli infection

growth/size/body

decreased body weight ( J:333437 )

• at 7-10 months of age

enlarged spleen ( J:333437 )

• at 7-10 months of age

renal/urinary system

abnormal kidney morphology ( J:333437 )

• kidney IgG deposits at 7-10 months of age

homeostasis/metabolism

increased circulating interleukin-17 level ( J:333437 )

• increased IL17a level at 7-10 months of age

increased circulating interleukin-6 level ( J:333437 )

• at 7-10 months of age

increased circulating tumor necrosis factor level ( J:333437 )

• at 7-10 months of age

cellular

abnormal dendritic cell migration ( J:333437 )

• reduced migration towards draining lymph nodes

• however, proportion of CD103+ CD11b- cDC1 and CD103- CD11b+ cDC2 in peripheral lung tissue are similar to controls

abnormal dendritic cell chemotaxis ( J:333437 )

• reduced migratory capacity in response to the ligand CCR7 but not CCL2 or CCL8 in mature dendritic cells

hematopoietic system

abnormal dendritic cell migration ( J:333437 )

• reduced migration towards draining lymph nodes

• however, proportion of CD103+ CD11b- cDC1 and CD103- CD11b+ cDC2 in peripheral lung tissue are similar to controls

abnormal dendritic cell chemotaxis ( J:333437 )

• reduced migratory capacity in response to the ligand CCR7 but not CCL2 or CCL8 in mature dendritic cells

enlarged spleen ( J:333437 )

• at 7-10 months of age

decreased dendritic cell number ( J:333437 )

• decrease in the proportion of CD11c+ dendritic cells in the draining lymph nodes but not in the spleen

• no abnormalities are detected in the development from precursors or survival, maturation, or T cell stimulating capacity of dendritic cells

• decrease in the proportion of CCR7+ CD11c+ cDCs but not CCR7+ CD11c- cells in draining lymph nodes under steady state conditions or after DFNB stimulation

• decreased proportions of CD11c+ cDCs and CCR7+ cDCs in the spleen and draining lymph nodes at 7-10 months of age

• decrease in the proportion of migratory but not resident cDCs in draining lymph nodes at 7-10 months of age

increased B cell number ( J:333437 )

• increased frequency of CD19+ B cells in the spleen and draining lymph nodes at 7-10 months of age

decreased T helper 1 cell number ( J:333437 )

• decreased development at 7-10 months of age

increased T cell number ( J:333437 )

• increased frequency of CD3+ T cells in spleen and draining lymph nodes at 7-10 months of age

increased T-helper 17 cell number ( J:333437 )

• increased development of Th17 cells at 7-10 months of age

increased Ly6C high monocyte number ( J:333437 )

• increased frequency of Ly6c^hiCD11c^hi monocytes in the spleen and draining lymph nodes at 7-10 months of age

abnormal regulatory T cell morphology ( J:333437 )

• impaired development of CD25+ and FOXP3+ Treg cells in draining lymph nodes but not the spleen

• impaired development of CD25+ and FOXP3+ Treg cells at 7-10 months of age

increased immunoglobulin level ( J:333437 )

• at 7-10 months of age Ig levels are increased

increased IgG level ( J:333437 )

• kidney IgG deposits at 7-10 months of age