Phenotypes associated with this allele

• Allele Symbol: Kcne5^em1Mdcb
• Allele Name: endonuclease-mediated mutation 1, Max-Delbrueck-Center for Molecular Medicine Berlin
• Allele ID: MGI:7641768
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Kcne5^em1Mdcb/Y	C57BL/6NCrl-Kcne5^em1Mdcb	MGI:7641773

Genotype
MGI:7641773

ot1

• Allelic Composition: Kcne5^em1Mdcb/Y
• Genetic Background: C57BL/6NCrl-Kcne5^em1Mdcb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

ventricular tachycardia ( J:283729 )

♂ • mice show increased susceptibility to polymorphic ventricular tachycardia induction with a defined pacing protocol followed by 3 extra stimuli

ventricular premature beat ( J:283729 )

♂ • intracardiac ECG shows ventricular premature beats which are followed by postextrasystolic compensatory pauses

♂ • however, mice do not exhibit cardiac hypertrophy or overt structural defects

abnormal myocardial fiber currents ( J:283729 )

♂ • mean ventricular myocyte voltage-gated potassium current density is increased in the apex and in the subpopulation of septal myocytes that lack fast transient outward current (I[to,f])

♂ • the current increases arise from an apex-specific increase in slow transient outward current-1 (I[Kslow,1], conducted by Kv1.5) and (I[to,f], conducted by Kv4) and an increase in slow transient outward current-2 (I[Kslow,2], conducted by Kv2.1) in both apex and septum