Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Dyrk1b)#Yax
• Allele Name: transgene insertion, Xiaoxiang Yan
• Allele ID: MGI:7642197
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Dyrk1b)#Yax/0	involves: C57BL/6J	MGI:7643391

Genotype
MGI:7643391

tg1

• Allelic Composition: Tg(Myh6-Dyrk1b)#Yax/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:334531 )

• increased adolescent mortality

• however, no embryonic lethality or severe growth retardation after birth are seen

cardiovascular system

abnormal myocardial fiber mitochondrial morphology ( J:334531 )

• abnormal morphology and density

enlarged heart ( J:334531 )

• at 8 weeks of age

increased heart weight ( J:334531 )

• increased heart weight-to-tibia length ratio

increased heart left ventricle size ( J:334531 )

• left ventricular internal dimension, left ventricular end-diastolic volume, and left ventricular end-systolic volume are increased

decreased heart left ventricle wall thickness ( J:334531 )

cardiac fibrosis ( J:334531 )

decreased cardiac muscle contractility ( J:334531 )

• marked contractile dysfunction and hear failure

• treatment with a STAT3 inhibitor at 4 weeks of age (S31-201) improves cardiac function

decreased ventricle muscle contractility ( J:334531 )

• stunning decline in left ventricular ejection fraction and left ventricular fraction shortening

abnormal response of heart to induced stress ( J:334531 )

• transverse aortic constriction rarely results in increased mitochondrial size or cristae disorganization unlike in wild-type mice

cellular

abnormal myocardial fiber mitochondrial morphology ( J:334531 )

• abnormal morphology and density

abnormal mitochondrial physiology ( J:334531 )

• expression analysis indicates impaired mitochondrial bioenergetics in hearts at 3 days of age

• decline in ATP content and NAD+ production in the heart

• dramatic decrease in basal, ATP production-coupled, and maximal respiration as well as spare respiratory capacity

abnormal mitochondrial ATP synthesis coupled electron transport ( J:334531 )

• dramatic reduction in ATP production coupled respiration in hearts

homeostasis/metabolism

abnormal response of heart to induced stress ( J:334531 )

• transverse aortic constriction rarely results in increased mitochondrial size or cristae disorganization unlike in wild-type mice

growth/size/body

enlarged heart ( J:334531 )

• at 8 weeks of age

increased heart weight ( J:334531 )

• increased heart weight-to-tibia length ratio

muscle

abnormal myocardial fiber mitochondrial morphology ( J:334531 )

• abnormal morphology and density

decreased cardiac muscle contractility ( J:334531 )

• marked contractile dysfunction and hear failure

• treatment with a STAT3 inhibitor at 4 weeks of age (S31-201) improves cardiac function

decreased ventricle muscle contractility ( J:334531 )

• stunning decline in left ventricular ejection fraction and left ventricular fraction shortening