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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dyrk1bem1Yax
endonuclease-mediated mutation 1, Xiaoxiang Yan
MGI:7642198
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dyrk1bem1Yax/Dyrk1bem1Yax Not Specified MGI:7643390


Genotype
MGI:7643390
hm1
Allelic
Composition		 Dyrk1bem1Yax/Dyrk1bem1Yax
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dyrk1bem1Yax mutation (0 available); any Dyrk1b mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:334531 )
N
• unlike transgenic mice with cardiac overexpression of DYRK1B, lifespan and growth are similar to wild-type controls

cardiovascular system
decreased response of heart to induced stress ( J:334531 )
• attenuation of transverse aortic constriction induced cardiac hypertrophy and heart failure at 4 weeks after surgery

homeostasis/metabolism
decreased response of heart to induced stress ( J:334531 )
• attenuation of transverse aortic constriction induced cardiac hypertrophy and heart failure at 4 weeks after surgery




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory