Analysis Tools
cardiovascular system
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• P14 cardiomyocytes are smaller, with reduction in cardiomyocyte length and width
• however, cardiomyocyte size is not different from wild-type in adult mice
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• hearts show an increase in population of cardiomyocytes at P14
• the percentage of mononuclear cardiomyocytes (the cells with proliferation potential) is increased in adult hearts and the total number of cardiomyocytes is increased in adult hearts
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• the heart-to-body weight ratio is increased in adults, however cardiomyocyte size is not different from wild-type indicating no cardiomyocyte hypertrophy in adults
• however, mice show normal heart size, heart-to-body weight ratio and cardiac function at P14 and mice develop normally to adulthood, without significant alternations in cardiac phenotype or cardiac function and cardiac morphology and function are normal at P60
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• the mitosis marker pH3 and cytokinesis marker Aurora B kinase are increased in cardiomyocytes at P14 and in adults and hearts show increased number of EdU+ cardiomyocytes at P14 and in adults, indicating increased cardiomyocyte proliferation
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• mice subjected to coronary artery occlusion show improved cardiac function (increased left ventricular posterior wall thickness, left ventricular ejection fraction, and fractional shortening), smaller scar size, and increased cardiomyocyte proliferation compared to controls at 14 and 60 days after myocardial infraction, indicating protection from myocardial infraction-induced injury
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• mice show smaller scar size at 14 and 60 days after myocardial infraction
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growth/size/body
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• the heart-to-body weight ratio is increased in adults, however cardiomyocyte size is not different from wild-type indicating no cardiomyocyte hypertrophy in adults
• however, mice show normal heart size, heart-to-body weight ratio and cardiac function at P14 and mice develop normally to adulthood, without significant alternations in cardiac phenotype or cardiac function and cardiac morphology and function are normal at P60
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homeostasis/metabolism
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• mice subjected to coronary artery occlusion show improved cardiac function (increased left ventricular posterior wall thickness, left ventricular ejection fraction, and fractional shortening), smaller scar size, and increased cardiomyocyte proliferation compared to controls at 14 and 60 days after myocardial infraction, indicating protection from myocardial infraction-induced injury
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• mice show smaller scar size at 14 and 60 days after myocardial infraction
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muscle
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• P14 cardiomyocytes are smaller, with reduction in cardiomyocyte length and width
• however, cardiomyocyte size is not different from wild-type in adult mice
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• hearts show an increase in population of cardiomyocytes at P14
• the percentage of mononuclear cardiomyocytes (the cells with proliferation potential) is increased in adult hearts and the total number of cardiomyocytes is increased in adult hearts
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