Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Actc1dt)2Kwan
• Allele Name: transgene insertion 2, Kun Wang
• Allele ID: MGI:7642226
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Actc1dt)2Kwan/0	involves: C57BL/6	MGI:7642228

Genotype
MGI:7642228

tg1

• Allelic Composition: Tg(Myh6-Actc1dt)2Kwan/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased myocardial fiber number ( J:297375 )

• total number of cardiomyocytes is decreased in adult hearts

increased myocardial fiber size ( J:297375 )

• cardiomyocyte size is increased

cardiac hypertrophy ( J:297375 )

• expression of cardiac hypertrophy markers such as atrial natriuretic factor and beta myosin heavy chain are increased in the heart, indicating cardiac hypertrophy

• isolated cardiomyocytes show increased hypertrophic response as indicated by sarcomere organization, increased cell surface area, increased protein synthesis, and elevated hypertrophy markers

decreased fetal cardiomyocyte proliferation ( J:297375 )

• neonatal hearts show a decrease in the number of cardiomyocytes with mitotic marker pH3 and EdU label, indicating reduced proliferation

increased susceptibility to myocardial ischemic injury ( J:297375 )

• mice subjected to left anterior-descending ligation at P1 show fewer proliferating cardiomyocytes at day 7 after myocardial infarction, depressed contractile function, fibrotic area is progressively increased compared to wild-type neonatal hearts which regenerate well with little fibrosis, indicating inhibition of neonatal heart regeneration

cellular

decreased fetal cardiomyocyte proliferation ( J:297375 )

• neonatal hearts show a decrease in the number of cardiomyocytes with mitotic marker pH3 and EdU label, indicating reduced proliferation

growth/size/body

cardiac hypertrophy ( J:297375 )

• expression of cardiac hypertrophy markers such as atrial natriuretic factor and beta myosin heavy chain are increased in the heart, indicating cardiac hypertrophy

• isolated cardiomyocytes show increased hypertrophic response as indicated by sarcomere organization, increased cell surface area, increased protein synthesis, and elevated hypertrophy markers

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:297375 )

• mice subjected to left anterior-descending ligation at P1 show fewer proliferating cardiomyocytes at day 7 after myocardial infarction, depressed contractile function, fibrotic area is progressively increased compared to wild-type neonatal hearts which regenerate well with little fibrosis, indicating inhibition of neonatal heart regeneration

muscle

decreased myocardial fiber number ( J:297375 )

• total number of cardiomyocytes is decreased in adult hearts

increased myocardial fiber size ( J:297375 )

• cardiomyocyte size is increased

decreased fetal cardiomyocyte proliferation ( J:297375 )

• neonatal hearts show a decrease in the number of cardiomyocytes with mitotic marker pH3 and EdU label, indicating reduced proliferation