Phenotypes associated with this allele

• Allele Symbol: Il1r2^tm1.2Mchc
• Allele Name: targeted mutation 1.2, Murray CH Clarke
• Allele ID: MGI:7643174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1r2^tm1.2Mchc/Il1r2^tm1.2Mchc	involves: BALB/cJ * C57BL/6J * C57BL/6NTac	MGI:7643352

Genotype
MGI:7643352

hm1

• Allelic Composition: Il1r2^tm1.2Mchc/Il1r2^tm1.2Mchc
• Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD4-positive, alpha-beta T cell number ( J:347877 )

• mice challenged with sheep red blood cell (sRBC) immunization show increased CD4+ T cell numbers

abnormal CD8-positive, alpha-beta T cell number ( J:347877 )

• mice challenged with sRBC immunization show altered CD8 subtype ratio and increased IFN-gamma+ CD8+ T cells

abnormal T cell physiology ( J:347877 )

• mice challenged with sRBC immunization show altered T cell function, with increased CD4+ T cell numbers, altered CD8 subtype ratio, and increased IFN-gamma+ CD8+ T cells

• however, sRBC challenged mice show no changes to Treg, T follicular (Tfol) cell, or germinal center B cell number or anti-sRBC IgG titers

increased circulating interleukin-1 alpha level ( J:347877 )

• mice injected with human IL-1alpha, show increased serum levels of IL-1alpha, indicating reduced clearance of IL-1alpha from the circulation

increased circulating interleukin-6 level ( J:347877 )

• mice intravenously injected with IL-1alpha, show higher serum IL-6 levels after 4 hours but not after 2 hours, indicating a prolonged inflammatory response

increased inflammatory response ( J:347877 )

• in a peritonitis model, mice show increased neutrophil recruitment into the peritoneum 6 hours after injection of IL-1alpha

• mice intravenously injected with IL-1alpha, show higher serum IL-6 levels indicating prolonged inflammatory response and increased serum levels of IL-1alpha, indicating reduced clearance of IL-1alpha from the circulation

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:347877 )

• mice challenged with sheep red blood cell (sRBC) immunization show increased CD4+ T cell numbers

abnormal CD8-positive, alpha-beta T cell number ( J:347877 )

• mice challenged with sRBC immunization show altered CD8 subtype ratio and increased IFN-gamma+ CD8+ T cells

abnormal T cell physiology ( J:347877 )

• mice challenged with sRBC immunization show altered T cell function, with increased CD4+ T cell numbers, altered CD8 subtype ratio, and increased IFN-gamma+ CD8+ T cells

• however, sRBC challenged mice show no changes to Treg, T follicular (Tfol) cell, or germinal center B cell number or anti-sRBC IgG titers

homeostasis/metabolism

increased circulating interleukin-1 alpha level ( J:347877 )

• mice injected with human IL-1alpha, show increased serum levels of IL-1alpha, indicating reduced clearance of IL-1alpha from the circulation

increased circulating interleukin-6 level ( J:347877 )

• mice intravenously injected with IL-1alpha, show higher serum IL-6 levels after 4 hours but not after 2 hours, indicating a prolonged inflammatory response