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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnf149em1Staa
endonuclease-mediated mutation 1, Ariel Stanhill
MGI:7643433
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rnf149em1Staa/Rnf149em1Staa involves: BALB/c * C57BL/6 MGI:7643438


Genotype
MGI:7643438
hm1
Allelic
Composition		 Rnf149em1Staa/Rnf149em1Staa
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf149em1Staa mutation (0 available); any Rnf149 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased leukocyte cell number ( J:335358 )
• at 6 months of age
increased neutrophil cell number ( J:335358 )
• at 6 months of age
increased lymphocyte cell number ( J:335358 )
• at 6 months of age
increased monocyte cell number ( J:335358 )
• at 6 months of age

cellular
increased cell proliferation ( J:335358 )
• hyperproliferation of several hematological lineages
abnormal fibroblast physiology ( J:335358 )
• increased translocation of VCAM1 into the endoplasmic reticulum in MEFs

immune system
increased leukocyte cell number ( J:335358 )
• at 6 months of age
increased neutrophil cell number ( J:335358 )
• at 6 months of age
increased lymphocyte cell number ( J:335358 )
• at 6 months of age
increased monocyte cell number ( J:335358 )
• at 6 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory