All Phenotypes Slc28a1<em1Govr> MGI Mouse

mortality/aging ( J:336148 )

N	• despite anemia no increase in mortality is seen at any age

anemia ( J:336148 )

• less severe than in Slc29a3 null mice

decreased erythrocyte cell number ( J:336148 )

• at 20 weeks of age

decreased hematocrit ( J:336148 )

• at 20 weeks of age

reticulocytosis ( J:336148 )

• compensatory increase in the number of reticulocytes and differential reticulocyte count at 20 weeks of age

homeostasis/metabolism phenotype ( J:336148 )

N	• albuminuria is not observed and average urinary creatinine levels are similar to controls

• increased serum creatinine at 20 weeks of age

abnormal urine nucleoside level ( J:336148 )

• elevated levels of pyrimidine (deoxy)nucleosides (uridine, cytidine, deoxyuridine, deoxycytidine, and deoxythymidine) in the urine

• however, levels of purine (deoxy)nucleosides are not significantly different

abnormal metabolism ( J:336148 )

• significant changes to both the urine and plasma metabolomes related to changes in purine and pyrimidine metabolism

• decreased plasma levels of nucleoside drugs due to increased urinary loss

• decreased therapeutic efficacy of anticancer drug gemcitabine that can be compensated by increasing the dose

abnormal urine nucleoside level ( J:336148 )

• elevated levels of pyrimidine (deoxy)nucleosides (uridine, cytidine, deoxyuridine, deoxycytidine, and deoxythymidine) in the urine

• however, levels of purine (deoxy)nucleosides are not significantly different

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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