Phenotypes associated with this allele

• Allele Symbol: Nsd3^tm1.1Caox
• Allele Name: targeted mutation 1.1, Xuetao Cao
• Allele ID: MGI:7643542
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lyz2^tm1(cre)Ifo/Lyz2^+ Nsd3^tm1.1Caox/Nsd3^tm1.1Caox	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	MGI:7643543

Genotype
MGI:7643543

cn1

• Allelic Composition: Lyz2^tm1(cre)Ifo/Lyz2⁺; Nsd3^tm1.1Caox/Nsd3^tm1.1Caox
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:251909 )

• mice infected with vesicular stomatitis virus (VSV) show shorter survival times and higher mortality than controls

immune system

decreased macrophage cytokine production ( J:251909 )

• peritoneal macrophages express lower levels of IFN-beta and produce lower levels of IL-6, TNF, IL-8, and COX-2 upon VSV infection

• however, macrophage differentiation and cell viability are unaffected in mice under basal conditions

increased susceptibility to Riboviria infection ( J:251909 )

• mice are more susceptible to VSV infection, showing a lower level of IFN-beta in serum and organs, increased VSV replication and titers in organs, more obvious infiltration of inflammatory cells and more severe tissue damage in lungs, and shorter survival and higher mortality

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:251909 )

• mice infected with vesicular stomatitis virus (VSV) show shorter survival times and higher mortality than controls

hematopoietic system

decreased macrophage cytokine production ( J:251909 )

• peritoneal macrophages express lower levels of IFN-beta and produce lower levels of IL-6, TNF, IL-8, and COX-2 upon VSV infection

• however, macrophage differentiation and cell viability are unaffected in mice under basal conditions