Phenotypes associated with this allele

• Allele Symbol: Hmgxb4^tm1.2Zhji
• Allele Name: targeted mutation 1.2, Jiliang Zhou
• Allele ID: MGI:7643694
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmgxb4^tm1.2Zhji/Hmgxb4^tm1.2Zhji	B6(Cg)-Hmgxb4^tm1.2Zhji	MGI:7643708

Genotype
MGI:7643708

hm1

• Allelic Composition: Hmgxb4^tm1.2Zhji/Hmgxb4^tm1.2Zhji
• Genetic Background: B6(Cg)-Hmgxb4^tm1.2Zhji

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:302603 )

• mice injected with a lethal dose of lipopolysaccharide (LPS) or undergoing cecal ligation and puncture (CLP) to induce endotoxemia or polymicrobial-induced sepsis, respectively, show prolonged survival time

immune system

decreased macrophage nitric oxide production ( J:302603 )

• LPS-induced nitric oxide production in macrophages is blunted

decreased susceptibility to endotoxin shock ( J:302603 )

• mice injected with a lethal dose of LPS to induce endotoxemia show prolonged survival time

• mice challenged with a low dose of LPS to induce acute lung injury show reduced alveolar congestion and infiltration of inflammatory cells, attenuated cell apoptosis and macrophage infiltration, reduced pulmonary vascular hyperpermeability, and blunted nitric oxide production, indicating protection from LPS-induced acute lung inury

• mice challenged with a low dose of LPS show protection from kidney injury

homeostasis/metabolism

decreased macrophage nitric oxide production ( J:302603 )

• LPS-induced nitric oxide production in macrophages is blunted

hematopoietic system

decreased macrophage nitric oxide production ( J:302603 )

• LPS-induced nitric oxide production in macrophages is blunted

cardiovascular system

decreased vascular permeability ( J:302603 )

• LPS-induced pulmonary vascular hyperpermeability is reduced