Phenotypes associated with this allele

• Allele Symbol: Tac2^em1Ysfk
• Allele Name: endonuclease-mediated mutation 1, Yoshinori Fukui
• Allele ID: MGI:7643902
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tac2^em1Ysfk/Tac2^em1Ysfk	C57BL/6-Tac2^em1Ysfk	MGI:7643964
cx2	Dock8^tm1Ysfk/Dock8^tm1Ysfk Tac2^em1Ysfk/Tac2^em1Ysfk Tg(TcrAND)53Hed/0	involves: C57BL/6 * SJL	MGI:7643975

Genotype
MGI:7643964

hm1

• Allelic Composition: Tac2^em1Ysfk/Tac2^em1Ysfk
• Genetic Background: C57BL/6-Tac2^em1Ysfk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased pruritus ( J:305132 )

• mice are less sensitive to IL-31 induced scratching

• however, mice show normal sensitivity to intradermal injection of histamine, chloroquine, or protease-activated receptor 2 agonist (SLIGRL-NH2)-induced scratching

nervous system

decreased neurotransmitter release ( J:305132 )

• gastrin-releasing peptide (GRP) release is hardly detected in primary dorsal root ganglion neurons in response to IL-31 as it is seen in wild-type neurons

Genotype
MGI:7643975

cx2

• Allelic Composition: Dock8^tm1Ysfk/Dock8^tm1Ysfk; Tac2^em1Ysfk/Tac2^em1Ysfk; Tg(TcrAND)53Hed/0
• Genetic Background: involves: C57BL/6 * SJL

integument

integument phenotype ( J:305132 )

N • mice show improved skin inflammation and scratching behavior compared to Dock8^tm1Ysfk/Dock8^tm1Ysfk Tg(TcrAND)53Hed/0 mice, without affecting serum IL-31 levels