All Phenotypes Tac2<em2Ysfk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tac2^em2Ysfk
endonuclease-mediated mutation 2, Yoshinori Fukui
MGI:7643915

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tac2^em2Ysfk/Tac2^em2Ysfk	C57BL/6-Tac2^em2Ysfk	MGI:7643970
cx2	Dock8^tm1Ysfk/Dock8^tm1Ysfk Tac2^em2Ysfk/Tac2^em2Ysfk Tg(TcrAND)53Hed/0	involves: C57BL/6 * SJL	MGI:7643976

Allelic Composition	Tac2^em2Ysfk/Tac2^em2Ysfk
Genetic Background	C57BL/6-Tac2^em2Ysfk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tac2^em2Ysfk mutation (0 available); any Tac2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

decreased pruritus ( J:305132 )

• mice are less sensitive to IL-31 induced scratching

• however, mice show normal sensitivity to intradermal injection of histamine, chloroquine, or protease-activated receptor 2 agonist (SLIGRL-NH2)-induced scratching

Allelic Composition	Dock8^tm1Ysfk/Dock8^tm1Ysfk Tac2^em2Ysfk/Tac2^em2Ysfk Tg(TcrAND)53Hed/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8^tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
Tac2^em2Ysfk mutation (0 available); any Tac2 mutation (18 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:305132 )

N	• mice show improved skin inflammation and scratching behavior compared to Dock8^tm1Ysfk/Dock8^tm1Ysfk Tg(TcrAND)53Hed/0 mice, without affecting serum IL-31 levels

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