Phenotypes associated with this allele

• Allele Symbol: Rnd2^tm1.1Jya
• Allele Name: targeted mutation 1.1, Junji Yamauchi
• Allele ID: MGI:7645342
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rnd2^tm1.1Jya/Rnd2^tm1.1Jya Tg(Plp1-cre/ERT)3Pop/0	B6.Cg-Rnd2^tm1.1Jya Tg(Plp1-cre/ERT)3Pop	MGI:7645369
cn2	Rnd2^tm1.1Jya/Rnd2^tm1.1Jya Tg(Mbp-cre)9Gvn/0	involves: C57BL/6 * FVB/N	MGI:7645354

Genotype
MGI:7645369

cn1

• Allelic Composition: Rnd2^tm1.1Jya/Rnd2^tm1.1Jya; Tg(Plp1-cre/ERT)3Pop/0
• Genetic Background: B6.Cg-Rnd2^tm1.1Jya Tg(Plp1-cre/ERT)3Pop

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased myelin sheath thickness ( J:309719 )

• mice show decreased myelin thickness in the corpus callosum 2 weeks after tamoxifen administration, with increased average g-ratios

increased myelin sheath thickness ( J:309719 )

• mice show increased myelin thickness 4 weeks after tamoxifen administration, with decreased average g-ratios

abnormal myelination ( J:309719 )

• mice show decreased myelin thickness in the corpus callosum two weeks after tamoxifen administration and increased myelin thickness four weeks after tamoxifen administration

• mice treated with tamoxifen for 5 days at 8-9 weeks of age show decreased MBP staining in the brain and decreased expression levels of MBP and CNPase two weeks after tamoxifen administration and increased MBP staining in the brain and increased expression levels of MBP and CNPase four weeks after tamoxifen administration

Genotype
MGI:7645354

cn2

• Allelic Composition: Rnd2^tm1.1Jya/Rnd2^tm1.1Jya; Tg(Mbp-cre)9Gvn/0
• Genetic Background: involves: C57BL/6 * FVB/N

nervous system

decreased myelin sheath thickness ( J:309719 )

• myelin sheaths are thinner in 15-day-old mice, with increased average g-ratios

increased myelin sheath thickness ( J:309719 )

• myelin sheaths are thicker in 28-day-old mice and in 2-month old mice, with reduced average g-ratios, indicating that the increase in myelin thickness persists into adolescence

abnormal myelination ( J:309719 )

• mice show decreased myelin thickness in the corpus callosum at 14 days of age and increased myelin thickness at 28 days of age, indicating positive regulation of myelin in the early myelinating period and negative regulation of myelination in the later period

• mice show decreased MBP staining and decreased MBP and CNPase expression levels at 14 days of age, but increased levels at 28 days of age

• however, the number of oligodendrocytes are unchanged and staining for the astrocyte maker GFAP and neuron maker NeuN are normal