Phenotypes associated with this allele

• Allele Symbol: Isg20^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7645451
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Isg20^em1Cya/Isg20^em1Cya Tg(Cdh16-cre)91Igr/0	involves: C57BL/6N * ICR	MGI:7645488

Genotype
MGI:7645488

cn1

• Allelic Composition: Isg20^em1Cya/Isg20^em1Cya; Tg(Cdh16-cre)91Igr/0
• Genetic Background: involves: C57BL/6N * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased susceptibility to kidney reperfusion injury ( J:343183 )

• significantly aggravated renal injuries following ischemia/reperfusion injury with increase tubule epithelial cell death and exacerbated inflammation

• following ischemia/reperfusion levels of blood urea nitrogen and serum creatinine are increased compared to similarly treated wild-type controls

• elevated levels of oxidized RNA following ischemia/reperfusion injury compared to similarly treated wild-type controls

kidney inflammation ( J:343183 )

• more severe inflammation after ishcenia/reperfusion injury compared to similarly treated wild-type controls

homeostasis/metabolism

increased circulating creatinine level ( J:343183 )

• after ischemia/reperfusion injury compared to similarly treated wild-type mice

• baseline creatinine is similar to controls

increased blood urea nitrogen level ( J:343183 )

• after ischemia/reperfusion injury compared to similarly treated wild-type mice

• baseline BUN is similar to controls

increased susceptibility to kidney reperfusion injury ( J:343183 )

• significantly aggravated renal injuries following ischemia/reperfusion injury with increase tubule epithelial cell death and exacerbated inflammation

• following ischemia/reperfusion levels of blood urea nitrogen and serum creatinine are increased compared to similarly treated wild-type controls

• elevated levels of oxidized RNA following ischemia/reperfusion injury compared to similarly treated wild-type controls

immune system

kidney inflammation ( J:343183 )

• more severe inflammation after ishcenia/reperfusion injury compared to similarly treated wild-type controls