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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Isg20em1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7645451
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Isg20em1Cya/Isg20em1Cya
Tg(Cdh16-cre)91Igr/0 		involves: C57BL/6N * ICR MGI:7645488


Genotype
MGI:7645488
cn1
Allelic
Composition		 Isg20em1Cya/Isg20em1Cya
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: C57BL/6N * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isg20em1Cya mutation (0 available); any Isg20 mutation (20 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased susceptibility to kidney reperfusion injury ( J:343183 )
• significantly aggravated renal injuries following ischemia/reperfusion injury with increase tubule epithelial cell death and exacerbated inflammation
• following ischemia/reperfusion levels of blood urea nitrogen and serum creatinine are increased compared to similarly treated wild-type controls
• elevated levels of oxidized RNA following ischemia/reperfusion injury compared to similarly treated wild-type controls
kidney inflammation ( J:343183 )
• more severe inflammation after ishcenia/reperfusion injury compared to similarly treated wild-type controls

homeostasis/metabolism
increased circulating creatinine level ( J:343183 )
• after ischemia/reperfusion injury compared to similarly treated wild-type mice
• baseline creatinine is similar to controls
increased blood urea nitrogen level ( J:343183 )
• after ischemia/reperfusion injury compared to similarly treated wild-type mice
• baseline BUN is similar to controls
increased susceptibility to kidney reperfusion injury ( J:343183 )
• significantly aggravated renal injuries following ischemia/reperfusion injury with increase tubule epithelial cell death and exacerbated inflammation
• following ischemia/reperfusion levels of blood urea nitrogen and serum creatinine are increased compared to similarly treated wild-type controls
• elevated levels of oxidized RNA following ischemia/reperfusion injury compared to similarly treated wild-type controls

immune system
kidney inflammation ( J:343183 )
• more severe inflammation after ishcenia/reperfusion injury compared to similarly treated wild-type controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory