About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dph1em2Swei
endonuclease-mediated mutation 2, Shuo Wei
MGI:7645690
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dph1em1Swei/Dph1em2Swei C57BL/6J-Dph1em1Swei Dph1em2Swei MGI:7645771
cx2
 		Cdkn1aem1Swei/Cdkn1a+
Dph1em1Swei/Dph1em2Swei 		involves: C57BL/6 MGI:7645772


Genotype
MGI:7645771
ht1
Allelic
Composition		 Dph1em1Swei/Dph1em2Swei
Genetic
Background		 C57BL/6J-Dph1em1Swei Dph1em2Swei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1em1Swei mutation (0 available); any Dph1 mutation (27 available)
Dph1em2Swei mutation (0 available); any Dph1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
small mandible ( J:347602 )
• in embryos
palatal shelves fail to meet at midline ( J:347602 )
• palatal shelves extend downwards in E14.5 embryos
• palatal shelves not fused in E15.5 embryos

digestive/alimentary system
palatal shelves fail to meet at midline ( J:347602 )
• palatal shelves extend downwards in E14.5 embryos
• palatal shelves not fused in E15.5 embryos

embryo
decreased embryo size ( J:347602 )
• from stage E10.5

growth/size/body
palatal shelves fail to meet at midline ( J:347602 )
• palatal shelves extend downwards in E14.5 embryos
• palatal shelves not fused in E15.5 embryos
decreased embryo size ( J:347602 )
• from stage E10.5

mortality/aging

skeleton
small mandible ( J:347602 )
• in embryos

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
diphthamide deficiency syndrome 1 DOID:0070477 OMIM:616901
 J:347602




Genotype
MGI:7645772
cx2
Allelic
Composition		 Cdkn1aem1Swei/Cdkn1a+
Dph1em1Swei/Dph1em2Swei
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1aem1Swei mutation (0 available); any Cdkn1a mutation (63 available)
Dph1em1Swei mutation (0 available); any Dph1 mutation (27 available)
Dph1em2Swei mutation (0 available); any Dph1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:347602 )
N
• fused palatal shelves in E15.5 embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory