All Phenotypes Hapstr1<tm1.1Menm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hapstr1^tm1.1Menm
targeted mutation 1.1, Marc L Mendillo
MGI:7645937

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Hapstr1^tm1.1Menm/Hapstr1^tm1.2Menm Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA	MGI:7646892
cn2	Hapstr1^tm1.1Menm/Hapstr1^tm1.2Menm Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: C57BL/6 * C57BL/6J * CBA	MGI:7646887
cn3	Hapstr1^tm1.1Menm/Hapstr1^tm1.1Menm Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:7646888

Allelic Composition	Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Hapstr1^tm1.1Menm/Hapstr1^tm1.2Menm Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Hapstr1^tm1.1Menm mutation (0 available); any Hapstr1 mutation (38 available)
Hapstr1^tm1.2Menm mutation (0 available); any Hapstr1 mutation (38 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (235 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:348964 )

Allelic Composition	Hapstr1^tm1.1Menm/Hapstr1^tm1.2Menm Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:348964 )

• die between E15 - E18.5

• present with no obvious abnormalities at E11.5

growth/size/body

decreased fetal size ( J:348964 )

• embryos present at E14.5 are smaller than littermates

cellular

decreased fibroblast proliferation ( J:348964 )

• proliferation is similar to controls shortly after plating but quickly drops off resulting in a 22-fold overall reduction in replicative potential

• knockdown of Trp53 expression partially rescues replication

Allelic Composition	Hapstr1^tm1.1Menm/Hapstr1^tm1.1Menm Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hapstr1^tm1.1Menm mutation (0 available); any Hapstr1 mutation (38 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:348964 )

• display robust weight loss over the span of 6 weeks after tamoxifen treatment at 3 months of age

• males lose at least 15% of their body weight after tamoxifen treatment

digestive/alimentary system

distended cecum ( J:348964 )

• 2 of 3 males showed massive swelling and distension of the cecum after tamoxifen treatment

large intestinal inflammation ( J:348964 )

• increased number of inflammatory foci in the colon that include larger lymphoid aggregates and smaller patches of infiltrating mononuclear cells after tamoxifen treatment

integument

abnormal hair growth ( J:348964 )

• tamoxifen treated mice show reduced regrowth of hair on hind limb following depilation

immune system

large intestinal inflammation ( J:348964 )

• increased number of inflammatory foci in the colon that include larger lymphoid aggregates and smaller patches of infiltrating mononuclear cells after tamoxifen treatment

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24