Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hapstr1tm1.1Menm targeted mutation 1.1, Marc L Mendillo MGI:7645937 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• die between E15 - E18.5
• present with no obvious abnormalities at E11.5
|
|
• embryos present at E14.5 are smaller than littermates
|
|
• proliferation is similar to controls shortly after plating but quickly drops off resulting in a 22-fold overall reduction in replicative potential
• knockdown of Trp53 expression partially rescues replication
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• display robust weight loss over the span of 6 weeks after tamoxifen treatment at 3 months of age
• males lose at least 15% of their body weight after tamoxifen treatment
|
 |
• 2 of 3 males showed massive swelling and distension of the cecum after tamoxifen treatment
|
|
• increased number of inflammatory foci in the colon that include larger lymphoid aggregates and smaller patches of infiltrating mononuclear cells after tamoxifen treatment
|
|
• tamoxifen treated mice show reduced regrowth of hair on hind limb following depilation
|
|
• increased number of inflammatory foci in the colon that include larger lymphoid aggregates and smaller patches of infiltrating mononuclear cells after tamoxifen treatment
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
