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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hapstr1tm1.2Menm
targeted mutation 1.2, Marc L Mendillo
MGI:7645942
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Edil3Tg(Sox2-cre)1Amc/Edil3+
Hapstr1tm1.1Menm/Hapstr1tm1.2Menm
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA MGI:7646892
cn2
 		Hapstr1tm1.1Menm/Hapstr1tm1.2Menm
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: C57BL/6 * C57BL/6J * CBA MGI:7646887


Genotype
MGI:7646892
cn1
Allelic
Composition		 Edil3Tg(Sox2-cre)1Amc/Edil3+
Hapstr1tm1.1Menm/Hapstr1tm1.2Menm
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Hapstr1tm1.1Menm mutation (0 available); any Hapstr1 mutation (38 available)
Hapstr1tm1.2Menm mutation (0 available); any Hapstr1 mutation (38 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7646887
cn2
Allelic
Composition		 Hapstr1tm1.1Menm/Hapstr1tm1.2Menm
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Hapstr1tm1.1Menm mutation (0 available); any Hapstr1 mutation (38 available)
Hapstr1tm1.2Menm mutation (0 available); any Hapstr1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:348964 )
• die between E15 - E18.5
• present with no obvious abnormalities at E11.5

growth/size/body
decreased fetal size ( J:348964 )
• embryos present at E14.5 are smaller than littermates

cellular
decreased fibroblast proliferation ( J:348964 )
• proliferation is similar to controls shortly after plating but quickly drops off resulting in a 22-fold overall reduction in replicative potential
• knockdown of Trp53 expression partially rescues replication




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory