Phenotypes associated with this allele

• Allele Symbol: Eif4h^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:7646937
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd79a^tm1(cre)Reth/Cd79a^+ Eif4b^tm1.1Tnr/Eif4b^tm1.1Tnr Eif4h^tm1c(EUCOMM)Wtsi/Eif4h^tm1c(EUCOMM)Wtsi	involves: BALB/c * C57BL/6 * C57BL/6N	MGI:7646989

Genotype
MGI:7646989

cn1

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Eif4b^tm1.1Tnr/Eif4b^tm1.1Tnr; Eif4h^{tm1c(EUCOMM)Wtsi}/Eif4h^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:344730 )

N • 7 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin B cell numbers are similar to immunized controls

decreased mature B cell number ( J:344730 )

• small reduction (25%) in mature/recirculating B cells

• normal numbers of splenic B cells and fractions of B-E B cells in the bone marrow

decreased IgG1 level ( J:344730 )

• small reduction in high-affinity IgG1 antibodies at 14 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin

immune system

decreased mature B cell number ( J:344730 )

• small reduction (25%) in mature/recirculating B cells

• normal numbers of splenic B cells and fractions of B-E B cells in the bone marrow

decreased IgG1 level ( J:344730 )

• small reduction in high-affinity IgG1 antibodies at 14 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin